ArticleAntimicrobial agents and chemotherapy2010
Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Echinocandins - structure, mechanism of action and use in antifungal therapy.Journal of enzyme inhibition and medicinal chemistry · 2022Review
- Review on Current Status of Echinocandins Use.Antibiotics (Basel, Switzerland) · 2020Review
- Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human PathogensFrontiers in genetics · 2020Article
- Aspergillus fumigatus-Related Species in Clinical Practice.Frontiers in microbiology · 2016Review
- Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr.Antimicrobial agents and chemotherapy · 2014Article
- A Case Report on Aspergillus lentulus Pneumonia.Balkan medical journal · 2013Article
- Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility.Journal of clinical microbiology · 2013Article
- Discovery of a sexual cycle in Aspergillus lentulus, a close relative of A. fumigatus.Eukaryotic cell · 2013Article
- Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.Antimicrobial agents and chemotherapy · 2011Article
- Evaluation of Luminex xTAG fungal analyte-specific reagents for rapid identification of clinically relevant fungi.Journal of clinical microbiology · 2011Article
- In vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the Transplant-Associated Infection Surveillance Network.Antimicrobial agents and chemotherapy · 2011Article
- Comparative proteomic profiles of Aspergillus fumigatus and Aspergillus lentulus strains by surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS).BMC microbiology · 2011Article
- Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature.European journal of medical research · 2011Review
- Current perspectives on echinocandin class drugs.Future microbiology · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The recently described species Aspergillus lentulus exhibits differential and reduced susceptibilities to echinocandins and other antifungal drugs in vitro. A. lentulus isolates overall are less susceptible to caspofungin, although they maintain susceptibility to anidulafungin and micafungin. Mutations or polymorphisms in fks, the gene encoding the catalytic subunit of β-1,3-glucan synthase, are known to confer decreased susceptibility to echinocandins in Candida spp. and Aspergillus fumigatus. The analysis of the A. lentulus fks sequence did not reveal a polymorphism at any of the known hot-spot regions of the gene. Caspofungin and micafungin kinetic inhibition profiles of the A. lentulus glucan synthase were comparable to those from susceptible A. fumigatus enzymes. Although the basal cell wall chitin levels in A. lentulus averaged 60% of those in A. fumigatus, echinocandin treatment promoted the increase of cell wall chitin in both organisms, indicating that A. lentulus displays a compensatory chitin response similar to that of A. fumigatus. The data suggest that differential echinocandin susceptibilities in A. lentulus are independent of the echinocandin target, Fksp, and they emphasize the potential that the drugs' capacity to inhibit the target enzyme is unequal at the cellular level.
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