ArticleProceedings of the National Academy of Sciences of the United States of America2010
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 111 citations in OpenAlex.
- Listeria promotes systemic infection by targeting the host deubiquitinase CYLD.Nature communications · 2026Article
- Listeriosis: a re-emerging threat to public health-a comprehensive review of its epidemiology, pathogenesis, and control measures.Infection · 2026Review
- Review
- Tissue- and time-dependent modulation of JAK/STAT pathway genes in Tenebrio molitor during Listeria monocytogenes infection.World journal of microbiology & biotechnology · 2026Article
- Proximity labeling of thebioRxiv : the preprint server for biology · 2026Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
- Review
- Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025Review
- The PrfA regulon ofMicrobiology (Reading, England) · 2024Article
- Listeria in Pregnancy-The Forgotten Culprit.Microorganisms · 2024Review
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Article
- Biological Characteristics of Listeria monocytogenes Following Deletion of TatD-like Protein Gene.Current microbiology · 2023Article
- A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.Scientific reports · 2022Article
- Comparative Genomics Reveal the Utilization Ability of Variable Carbohydrates as Key Genetic Features ofPathogens (Basel, Switzerland) · 2022Article
- Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.Infection and immunity · 2022Review
- Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling.Frontiers in cell and developmental biology · 2022Review
- IκBFrontiers in immunology · 2022Article
- Pathogenicity and virulence ofVirulence · 2021Article
- Bacterial Biofilms and Their Implications in Pathogenesis and Food Safety.Foods (Basel, Switzerland) · 2021Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Listeria monocytogenes is an intracellular pathogen responsible for severe foodborne infections. It can replicate in both phagocytic and nonphagocytic mammalian cells. The infectious process at the cellular level has been studied extensively, but how the bacterium overcomes early host innate immune responses remains largely unknown. Here we show that InlC, a member of the internalin family, is secreted intracellularly and directly interacts with IKKα, a subunit of the IκB kinase complex critical for the phosphorylation of IκB and activation of NF-κB, the major regulator of innate immune responses. Infection experiments with WT Listeria or the inlC-deletion mutant and transfection of cells with InlC reveal that InlC expression impairs phosphorylation and consequently delays IκB degradation normally induced by TNF-α, a classical NF-κB stimulator. Moreover, infection of RAW 264.7 macrophages by the inlC mutant leads to increased production of proinflammatory cytokines compared with that obtained with the WT. Finally, in a peritonitis mouse model, we show that infection with the inlC mutant induces increased production of chemokines and increased recruitment of neutrophils in the peritoneal cavity compared with infection with WT. Together, these results demonstrate that InlC, by interacting with IKKα, dampens the host innate response induced by Listeria during the infection process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.