ArticleProceedings of the National Academy of Sciences of the United States of America2010
Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.
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Who cites it
166 citing papers in PubMed.
- Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Graph theoretical analysis of brain connectivity in phantom sound perception.Scientific reports · 2016Trial
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- Acute ethanol enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging.Alcohol (Fayetteville, N.Y.) · 2026Article
- High-frequency bursts facilitate fast communication for human spatial attention.Nature neuroscience · 2026Article
- Orthogonal-Rotational Dynamics Supports Efficient Encoding and Updating for Streaming Information in Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Task-invariant anterior-to-posterior large-scale phase gradients of electrocorticogram oscillations during picture naming and wrist extension.Communications biology · 2025Article
- Layer-specific cortical dynamics during transitions from error monitoring to decision execution in reversal learning.Communications biology · 2025Article
- Untangling cross-regional cross-frequency coupling in dynamic neural oscillations.Journal of neural engineering · 2025Article
- Panx1a modulates metabolic stress signaling and synaptic composition in the developing zebrafish brain.Cell and tissue research · 2025Article
- Abnormal phase-amplitude coupling in patients with first-episode schizophrenia during the auditory steady-state response and resting states.Medical & biological engineering & computing · 2025Article
- Homeostatic bidirectional plasticity in upbound and downbound micromodules in a model of the olivocerebellar loop.PLoS computational biology · 2025Article
- Human neuronal firing is modulated by the frequency of local field potential oscillations.bioRxiv : the preprint server for biology · 2025Article
- Time-domain brain: temporal mechanisms for brain functions using time-delay nets, holographic processes, radio communications, and emergent oscillatory sequences.Frontiers in computational neuroscience · 2025Article
- On the ability of standard and brain-constrained deep neural networks to support cognitive superposition: a position paper.Cognitive neurodynamics · 2024Article
- Multimodal gradients of basal forebrain connectivity across the neocortex.Nature communications · 2024Article
- Investigating the Effects of Transcranial Alternating Current Stimulation on Cortical Oscillations and Network Dynamics.Brain sciences · 2024Article
- EEG band power and phase-amplitude coupling in patients with Dravet syndrome.Annals of the Child Neurology Society · 2024Article
- The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study.Addiction biology · 2024Article
- Cortico-cerebellar coordination facilitates neuroprosthetic control.Science advances · 2024Article
106 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence for brain mechanisms that coordinate multiple coactive assemblies remains lacking. Neuronal oscillations have been suggested as one possible mechanism for cell assembly coordination. Prior studies have shown that spike timing depends upon local field potential (LFP) phase proximal to the cell body, but few studies have examined the dependence of spiking on distal LFP phases in other brain areas far from the neuron or the influence of LFP-LFP phase coupling between distal areas on spiking. We investigated these interactions by recording LFPs and single-unit activity using multiple microelectrode arrays in several brain areas and then used a unique probabilistic multivariate phase distribution to model the dependence of spike timing on the full pattern of proximal LFP phases, distal LFP phases, and LFP-LFP phase coupling between electrodes. Here we show that spiking activity in single neurons and neuronal ensembles depends on dynamic patterns of oscillatory phase coupling between multiple brain areas, in addition to the effects of proximal LFP phase. Neurons that prefer similar patterns of phase coupling exhibit similar changes in spike rates, whereas neurons with different preferences show divergent responses, providing a basic mechanism to bind different neurons together into coordinated cell assemblies. Surprisingly, phase-coupling-based rate correlations are independent of interneuron distance. Phase-coupling preferences correlate with behavior and neural function and remain stable over multiple days. These findings suggest that neuronal oscillations enable selective and dynamic control of distributed functional cell assemblies.
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