ArticleProceedings of the National Academy of Sciences of the United States of America2011
Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed.
- Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals.Scientific reports · 2020Trial
- Interfering parameters in the determination of urinary globotriaosylceramide (Gb3) in patients with chronic kidney disease.Journal of nephrology · 2015Trial
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- Synthesis and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological Recognition.ACS medicinal chemistry letters · 2026Article
- Impact of maternal HIV infection on the gut microbiome and metabolome of mothers and infants: the PRACHITi cohort in Pune, India.Nature communications · 2026Article
- Directional Colony Growth of Cupriavidus toward Sphingomonads.Microbes and environments · 2026Article
- Lipid-derived microbial metabolites at the gut-liver interface: regulation of intestinal barrier function, immune signaling, and metabolic inflammation.Frontiers in physiology · 2026Review
- Genome-based reassessment ofCurrent research in microbial sciences · 2026Article
- Sphingolipid-mediated vesiculation in multidrug-resistantApplied and environmental microbiology · 2025Article
- Evolutionary and functional relationships between plant and microbial CThe New phytologist · 2025Review
- Lipidomics, Microbiota, and IntestinalInternational journal of molecular sciences · 2025Review
- Microbes with higher metabolic independence are enriched in human gut microbiomes under stress.eLife · 2025Article
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- Gut-Microbiota-Driven Lipid Metabolism: Mechanisms and Applications in Swine Production.Metabolites · 2025Review
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- The Multifaceted Impact of Bioactive Lipids on Gut Health and Disease.International journal of molecular sciences · 2024Review
- What defines a healthy gut microbiome?Gut · 2024Review
- Sewage and Organic Pollution Compounds in Nairobi River Urban Sediments Characterized by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS).Journal of the American Society for Mass Spectrometry · 2024Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As predominant intestinal symbiotic bacteria, Bacteroides are essential in maintaining the health of the normal mammalian host; in return, the host provides a niche with plentiful nutrients for the symbionts. However, the intestinal environment is replete with chemical, physical, and biological challenges that require mechanisms for prompt and adept sensing of and responses to stress if the bacteria are to survive. Herein we propose that to persist in the intestine Bacteroides take advantage of their unusual bacterial sphingolipids to mediate signaling pathways previously known to be available only to higher organisms. Sphingolipids convey diverse signal transduction and stress response pathways and have profound physiological impacts demonstrated in a variety of eukaryotic cell types. We propose a mechanism by which the formation of specific sphingolipid membrane microdomains initiates signaling cascades that facilitate survival strategies within the bacteria. Our preliminary data suggest that sphingolipid signaling plays an important role in Bacteroides physiology, enabling these bacteria to persist in the intestine and to perform other functions related to symbiosis.
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