ArticleProceedings of the National Academy of Sciences of the United States of America2010
Mutations of cellulose synthase (CESA1) phosphorylation sites modulate anisotropic cell expansion and bidirectional mobility of cellulose synthase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed, 163 citations in OpenAlex.
- A Guide to Reproducible Cellulose Synthase Density and Speed Measurements inBio-protocol · 2026Article
- Exploiting evolutionary diversity of cellulose synthase catalytic subunits to generate novel cellulose microfibril structure in Arabidopsis.Journal of experimental botany · 2026Article
- Cytoskeletal control of development and environmental adaptation in plants.Science China. Life sciences · 2026Review
- The GAs-RhMYB70 feedback loop fine-tunes cell expansion and petal size by modulating cellulose content in rose.Horticulture research · 2025Article
- Phosphate starvation regulates cellulose synthesis to modify root growth.Plant physiology · 2024Article
- The damage-associated molecular pattern cellotriose alters the phosphorylation pattern of proteins involved in cellulose synthesis andPlant signaling & behavior · 2023Article
- Signals and Their Perception for Remodelling, Adjustment and Repair of the Plant Cell Wall.International journal of molecular sciences · 2023Review
- Integrative pathway and network analysis provide insights on flooding-tolerance genes in soybean.Scientific reports · 2023Article
- Acoustic radiation force on a long cylinder, and potential sound transduction by tomato trichomes.Biophysical journal · 2022Article
- CORK1, A LRR-Malectin Receptor Kinase, Is Required for Cellooligomer-Induced Responses inCells · 2022Article
- Arabinogalactan Proteins: Focus on the Role in Cellulose Synthesis and Deposition during Plant Cell Wall Biogenesis.International journal of molecular sciences · 2022Review
- Secondary cell wall patterning-connecting the dots, pits and helices.Open biology · 2022Article
- The function and biosynthesis of callose in high plants.Heliyon · 2022Review
- Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase.The Plant cell · 2022Article
- Cell biology of primary cell wall synthesis in plants.The Plant cell · 2022Review
- Comparative Analysis of Herbaceous and Woody Cell Wall Digestibility by Pathogenic Fungi.Molecules (Basel, Switzerland) · 2021Article
- Xyloglucan Remodeling Defines Auxin-Dependent Differential Tissue Expansion in Plants.International journal of molecular sciences · 2021Article
- A Comparative Analysis of Transcription Networks Active in Juvenile and Mature Wood inFrontiers in plant science · 2021Article
- Global Profiling of Phosphorylation Reveals the Barley Roots Response to Phosphorus Starvation and Resupply.Frontiers in plant science · 2021Article
- Mutations in the Pectin Methyltransferase QUASIMODO2 Influence Cellulose Biosynthesis and Wall Integrity in Arabidopsis.The Plant cell · 2020Article
15 more citing papers are in PubMed but not listed here.
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3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The CESA1 component of cellulose synthase is phosphorylated at sites clustered in two hypervariable regions of the protein. Mutations of the phosphorylated residues to Ala (A) or Glu (E) alter anisotropic cell expansion and cellulose synthesis in rapidly expanding roots and hypocotyls. Expression of T166E, S686E, or S688E mutants of CESA1 fully rescued the temperature sensitive cesA1-1 allele (rsw1) at a restrictive temperature whereas mutations to A at these positions caused defects in anisotropic cell expansion. However, mutations to E at residues surrounding T166 (i.e., S162, T165, and S167) caused opposite effects. Live-cell imaging of fluorescently labeled CESA showed close correlations between tissue or cell morphology and patterns of bidirectional motility of CESA complexes in the plasma membrane. In the WT, CESA complexes moved at similar velocities in both directions along microtubule tracks. By contrast, the rate of movement of CESA particles was directionally asymmetric in mutant lines that exhibited abnormal tissue or cell expansion, and the asymmetry was removed upon depolymerizing microtubules with oryzalin. This suggests that phosphorylation of CESA differentially affects a polar interaction with microtubules that may regulate the length or quantity of a subset of cellulose microfibrils and that this, in turn, alters microfibril structure in the primary cell wall resulting in or contributing to the observed defect in anisotropic cell expansion.
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