ArticleProceedings of the National Academy of Sciences of the United States of America2010
Next-generation protein-rich potato expressing the seed protein gene AmA1 is a result of proteome rebalancing in transgenic tuber.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 114 citations in OpenAlex.
- Genetic architecture of seed protein composition in grain amaranth (Frontiers in nutrition · 2026Article
- Amaranth, the ancient pseudocereal: a promising crop for climate-resilient agriculture and healthy diets.Frontiers in plant science · 2026Review
- Comparative Analysis of Chromosome Repeat DNA Patterns in FourInternational journal of molecular sciences · 2025Article
- Biofortification of potato nutrition.Journal of advanced research · 2025Review
- Genotypic Diversity and Genome-Wide Association Study of Protein Content and Amino Acid Profile in Diverse Potato Accessions.Foods (Basel, Switzerland) · 2025Article
- Genome Studies inInternational journal of molecular sciences · 2024Article
- Next-generation marker-free transplastomic plants: engineering the chloroplast genome without integration of marker genes in Solanum tuberosum (potato).Plant cell reports · 2024Article
- Potato: from functional genomics to genetic improvement.Molecular horticulture · 2024Review
- Constitutive overexpression ofFrontiers in plant science · 2024Article
- Variations in Total Protein and Amino Acids in the Sequenced Sorghum Mutant Library.Plants (Basel, Switzerland) · 2023Article
- Ectopic expression of theFrontiers in plant science · 2023Article
- Genome Editing and Protein Energy Malnutrition.Advances in experimental medicine and biology · 2023Article
- Potato biofortification: an effective way to fight global hidden hunger.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Review
- Evolution and Application of Genome Editing Techniques for Achieving Food and Nutritional Security.International journal of molecular sciences · 2021Review
- Comparative proteome analyses of rhizomania resistant transgenic sugar beets based on RNA silencing mechanism.GM crops & food · 2021Article
- Employing CRISPR/Cas Technology for the Improvement of Potato and Other Tuber Crops.Frontiers in plant science · 2021Review
- Omics Technologies to Enhance Plant Based Functional Foods: An Overview.Frontiers in genetics · 2021Review
- Article
- Unraveling the Strategies Used by the Underexploited Amaranth Species to Confront Salt Stress: Similarities and Differences With Quinoa Species.Frontiers in plant science · 2021Article
- Prospects for potato genome editing to engineer resistance against viruses and cold-induced sweetening.GM crops & food · 2020Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein deficiency is the most crucial factor that affects physical growth and development and that increases morbidity and mortality especially in developing countries. Efforts have been made to improve protein quality and quantity in crop plants but with limited success. Here, we report the development of transgenic potatoes with enhanced nutritive value by tuber-specific expression of a seed protein, AmA1 (Amaranth Albumin 1), in seven genotypic backgrounds suitable for cultivation in different agro-climatic regions. Analyses of the transgenic tubers revealed up to 60% increase in total protein content. In addition, the concentrations of several essential amino acids were increased significantly in transgenic tubers, which are otherwise limited in potato. Moreover, the transgenics also exhibited enhanced photosynthetic activity with a concomitant increase in total biomass. These results are striking because this genetic manipulation also resulted in a moderate increase in tuber yield. The comparative protein profiling suggests that the proteome rebalancing might cause increased protein content in transgenic tubers. Furthermore, the data on field performance and safety evaluation indicate that the transgenic potatoes are suitable for commercial cultivation. In vitro and in vivo studies on experimental animals demonstrate that the transgenic tubers are also safe for human consumption. Altogether, these results emphasize that the expression of AmA1 is a potential strategy for the nutritional improvement of food crops.
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