ArticleInfection and immunity2010
Inhibition of T cells provides protection against early invasive pneumococcal disease.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Combination Adjuvants Enhance Recombinant Protein Vaccine Protection against Fungal Infection.mBio · 2021Article
- CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway.Cytokine · 2018Article
- Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree.PloS one · 2018Article
- Immune-responsiveness of CD4Scientific reports · 2016Article
- Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.Journal of immunology research · 2016Article
- L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.Infection and immunity · 2014Article
- Is boosting the immune system in sepsis appropriate?Critical care (London, England) · 2014Review
- Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection.PloS one · 2014Article
- Toll-like receptor 4 stimulation before or after Streptococcus pneumoniae induced sepsis improves survival and is dependent on T-cells.PloS one · 2014Article
- Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation.Clinical and experimental immunology · 2013Article
- Current concepts in host-microbe interaction leading to pneumococcal pneumonia.Current opinion in infectious diseases · 2013Review
- Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung.PLoS pathogens · 2013Article
- A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.Thorax · 2012Article
- Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Review
- Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets.British journal of pharmacology · 2012Review
- Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.PLoS pathogens · 2012Article
- A new synthesis for antibody-mediated immunity.Nature immunology · 2011Article
- The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response.Vaccine · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections caused by Streptococcus pneumoniae are major causes of morbidity and mortality, which are in part mediated by immune cell-dependent mechanisms. Yet, the specific contributions of individual cell types to immunopathology are only partially understood. T cells are well characterized with respect to their function in protective humoral immune responses; however, their roles during early stages of infection and invasive pneumococcal disease (IPD) are less well defined. Using a mouse model of pneumococcal sepsis, we found that CD4(+) T cells were recruited to the lung as early as 12 h after intranasal infection. Recruitment was accompanied by upregulation of CD69 and B7-H1, reflecting T-cell activation. Unexpectedly, major histocompatibility complex (MHC) class II-deficient mice, which lack CD4(+) T cells, displayed an increased survival despite comparable bacterial titers in the blood, spleen, and lung. The higher survival correlated with a lower cytokine and chemokine response upon S. pneumoniae challenge in MHC class II-deficient mice, suggesting that inflammation may contribute to the mortality of IPD. Comparable to the case for MHC class II-deficient mice, antibody-mediated depletion of CD4(+) T cells and drug-induced inhibition of T-cell function with cyclosporine, or interference with T-cell activation using CTLA4-immunoglobulin (Abatacept), led to significant increases in survival during IPD. Our results reveal an important and adverse role of CD4(+) T cells in the pathogenesis of IPD and suggest that modulation of T-cell activation during early phases of S. pneumoniae invasive infection may provide a therapeutic option.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.