ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2010
Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events: A Pilot Study
A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Influenza vaccination and the risk of myocardial infarction: a meta-epidemiology study.BMC public health · 2026Pooled it
- Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review.GeroScience · 2023Pooled it
- Protective effect of influenza vaccination on cardiovascular diseases: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Guideline
- Acute myocardial infarction and influenza: a meta-analysis of case-control studies.Heart (British Cardiac Society) · 2015Pooled it
- Review
- Is Influenza Vaccination Our Best 'Shot' at Preventing MACE? Review of Current Evidence, Underlying Mechanisms, and Future Directions.Vaccines · 2025Review
- Article
- [Vaccination and cardiovascular diseases].Herz · 2025Review
- Factors Affecting Influenza and Pneumococcal Vaccination Rates in Hemodialysis Patients: A Multicenter Study.Risk management and healthcare policy · 2025Article
- Pleiotropic Effects of Influenza Vaccination.Vaccines · 2023Review
- The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence.Human vaccines & immunotherapeutics · 2023Review
- Article
- Myocardial infarction and viral triggers: what do we know by now?European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Vaccines and cardiovascular outcomes: lessons learned from influenza epidemics.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
- A comprehensive overview of pneumococcal vaccination recommendations for adults in South Africa, 2022.Journal of thoracic disease · 2022Review
- Recommendations of the Italian society for infectious and tropical diseases (SIMIT) for adult vaccinations.Human vaccines & immunotherapeutics · 2021Article
- B Cells in Atherosclerosis: Mechanisms and Potential Clinical Applications.JACC. Basic to translational science · 2021Review
- Prognostic impact of high sensitive troponin in predicting 30-day mortality among patients admitted to hospital with influenza.International journal of cardiology. Heart & vasculature · 2021Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have shown an association between acute myocardial infarction and preceding respiratory infection. Contradictory evidence exists on the influence of influenza vaccination and pneumococcal vaccination in preventing cardiovascular disease. We aimed to investigate the possible association of influenza vaccination and pneumococcal vaccination with acute myocardial infarction.
methodsWe used a matched case-control design with data from the United Kingdom General Practice Research Database. Cases were patients who were at least 40 years of age at diagnosis of first acute myocardial infarction recorded from Nov.1, 2001, to May 31, 2007, and were matched for sex, general practice, age and calendar time (i.e., month corresponding to index date of acute myocardial infarction), with up to four controls each. Data were analyzed using conditional logistic regression, adjusted for vaccination target groups, cardiovascular risk factors, treatment medications and attendances at a general practice.
resultsWe included 78 706 patients, of whom 16 012 were cases and 62 694 were matched controls. Influenza vaccination had been received in the previous year by 8472 cases (52.9%) and 32 081 controls (51.2%) and was associated with a 19% reduction in the rate of acute myocardial infarction (adjusted odds ratio [OR] 0.81, 95% confidence interval [CI] 0.77-0.85). Early seasonal influenza vaccination was associated with a lower rate of acute myocardial infarction (adjusted OR 0.79, 95% CI 0.75-0.83) than vaccination after mid-November (adjusted OR 0.88, 95% CI 0.79-0.97). Pneumococcal vaccination was not associated with a reduction in the rate of acute myocardial infarction (adjusted OR 0.96, 95% CI 0.91-1.02).
interpretationInfluenza vaccination but not pneumococcal vaccination is associated with a reduced rate of first acute myocardial infarction. This association and the potential benefit of early seasonal vaccination need to be considered in future experimental studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.