ArticleGenome biology and evolution2010
Functional conservation of DNA methylation in the pea aphid and the honeybee.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 98 citations in OpenAlex.
- Article
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- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.BMC biology · 2023Article
- Pest status, molecular evolution, and epigenetic factors derived from the genome assembly of Frankliniella fusca, a thysanopteran phytovirus vector.BMC genomics · 2023Article
- A Broad Survey of Gene Body and Repeat Methylation in Cnidaria Reveals a Complex Evolutionary History.Genome biology and evolution · 2022Article
- DNA methylation across the tree of life, from micro to macro-organism.Bioengineered · 2022Article
- Reproductive Potential Impacts Body Maintenance Parameters and Global DNA Methylation in Honeybee Workers (Insects · 2021Article
- The role of epigenetics, particularly DNA methylation, in the evolution of caste in insect societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Comparative Epigenomics Reveals Host Diversity of theFrontiers in cell and developmental biology · 2021Article
- Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.Frontiers in genetics · 2020Article
- DNA Methylation and Demethylation Are Regulated by Functional DNA Methyltransferases and DnTET Enzymes inFrontiers in genetics · 2020Article
- Sex-specific changes in the aphid DNA methylation landscape.Molecular ecology · 2019Article
- What drives phenotypic divergence among coral clonemates of Acropora palmata?Molecular ecology · 2019Article
- The effects of the neonicotinoid imidacloprid on gene expression and DNA methylation in the buff-tailed bumblebee Bombus terrestris.Proceedings. Biological sciences · 2019Article
- Epigenetic mechanisms mediate the experimental evolution of resistance against parasitic fungi in the greater wax moth Galleria mellonella.Scientific reports · 2019Article
- Dietary Modulation of the Epigenome.Physiological reviews · 2018Review
- Genome-Wide Characterization of DNA Methylation in an Invasive Lepidopteran Pest, the Cotton BollwormG3 (Bethesda, Md.) · 2018Article
- Do social insects support Haig's kin theory for the evolution of genomic imprinting?Epigenetics · 2017Review
- Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.Genes · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
DNA methylation is a fundamental epigenetic mark known to have wide-ranging effects on gene regulation in a variety of animal taxa. Comparative genomic analyses can help elucidate the function of DNA methylation by identifying conserved features of methylated genes and other genomic regions. In this study, we used computational approaches to distinguish genes marked by heavy methylation from those marked by little or no methylation in the pea aphid, Acyrthosiphon pisum. We investigated if these two classes had distinct evolutionary histories and functional roles by conducting comparative analysis with the honeybee, Apis (Ap.) mellifera. We found that highly methylated orthologs in A. pisum and Ap. mellifera exhibited greater conservation of methylation status, suggesting that highly methylated genes in ancestral species may remain highly methylated over time. We also found that methylated genes tended to show different rates of evolution than unmethylated genes. In addition, genes targeted by methylation were enriched for particular biological processes that differed from those in relatively unmethylated genes. Finally, methylated genes were preferentially ubiquitously expressed among alternate phenotypes in both species, whereas genes lacking signatures of methylation were preferentially associated with condition-specific gene regulation expression. Overall, our analyses support a conserved role for DNA methylation in insects with comparable methylation systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.