ReviewAging cell2010
PAPP-A: a new anti-aging target?
Review in Aging cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Aging rate indicators and the search for anti-aging drugs.Frontiers in science · 2026Article
- PAPP-A as a Potential Target in Thyroid Eye Disease.The Journal of clinical endocrinology and metabolism · 2024Article
- GDF11 and aging biology - controversies resolved and pending.The journal of cardiovascular aging · 2023Article
- Structure of the PAPP-ANature communications · 2022Article
- Therapeutic Targeting of the IGF Axis.Cells · 2019Review
- Somatic growth, aging, and longevity.NPJ aging and mechanisms of disease · 2017Review
- The somatotropic axis and aging: Benefits of endocrine defects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2016Review
- Can aging be 'drugged'?Nature medicine · 2015Review
- Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Motor and memory testing of long-lived pregnancy-associated plasma protein--a knock-out mice.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2014Article
- Preferential expression of PAPPA in human preadipocytes from omental fat.The Journal of endocrinology · 2014Article
- Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice.Endocrinology · 2014Article
- Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy.The Journal of endocrinology · 2013Article
- Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.Physiological reviews · 2013Review
- Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress.Aging cell · 2012Article
- Insulin-like growth factor binding proteins: a structural perspective.Frontiers in endocrinology · 2012Article
- Comparative endocrinology of aging and longevity regulation.Frontiers in endocrinology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.