ArticleThe Journal of comparative neurology2010
Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis.Frontiers in oncology · 2024Pooled it
- Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain.Journal of neuroendocrinology · 2026Article
- Review
- Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.Frontiers in endocrinology · 2025Review
- Neural mechanisms of comforting: Prosocial touch and stress buffering.Hormones and behavior · 2023Review
- Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.Biology open · 2022Article
- Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).Journal of neuroendocrinology · 2022Review
- Article
- Anatomical Markers of Activity in Hypothalamic Neurons.Comprehensive Physiology · 2020Review
- Characterization and gonadal hormone regulation of a sexually dimorphic corticotropin-releasing factor receptor 1 cell group.The Journal of comparative neurology · 2019Article
- Thalamic integration of social stimuli regulating parental behavior and the oxytocin system.Frontiers in neuroendocrinology · 2018Review
- Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear.The Journal of comparative neurology · 2016Article
- Histamine receptor signaling in energy homeostasis.Neuropharmacology · 2016Review
- Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanism of H₂ histamine receptor dependent modulation of body temperature and neuronal activity in the medial preoptic nucleus.Neuropharmacology · 2012Article
- Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions.Brain structure & function · 2012Article
- Article
- The neuroendocrine functions of the parathyroid hormone 2 receptor.Frontiers in endocrinology · 2012Article
- Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in the subparafascicular area at the caudal border of the thalamus that contain the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) densely innervate several hypothalamic areas, including the paraventricular nucleus (PVN). These areas contain a matching distribution of TIP39's receptor, the parathyroid hormone receptor 2 (PTH2R). Frequent PTH2R coexpression with a vesicular glutamate transporter (VGlut2) suggests that TIP39 could presynaptically regulate glutamate release. By using immunohistochemistry we found CRH-ir neurons surrounded by PTH2R-ir fibers and TIP39-ir axonal projections in the PVN area of the mouse brain. Labeling hypothalamic neuroendocrine neurons by peripheral injection of fluorogold in PTH2R-lacZ knock-in mice showed that most PTH2Rs are on PVN and peri-PVN interneurons and not on neuroendocrine cells. Double fluorescent in situ hybridization revealed a high level of coexpression between PTH2R and VGlut2 mRNA by cells located in the PVN and nearby brain areas. Local TIP39 infusion (100 pmol) robustly increased pCREB-ir in the PVN and adjacent perinuclear zone. It also increased plasma corticosterone and decreased plasma prolactin. These effects of TIP39 on pCREB-ir, corticosterone, and prolactin were abolished by coinfusion of the ionotropic glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and DL-2-amino-5-phosphonopentanoic acid (AP-5; 30 pmol each) and were absent in PTH2R knockout mice. Basal plasma corticosterone was slightly decreased in TIP39 knockout mice just before onset of their active phase. The present data indicate that the TIP39 ligand/PTH2 receptor system provides facilitatory regulation of the hypothalamic-pituitary-adrenal axis via hypothalamic glutamatergic neurons and that it may regulate other neuroendocrine systems by a similar mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.