Evidence map›Paper›PMID 20853343›Full record

ArticleCurrent protocols in cell biology2010

Isolation of aggresomes and other large aggregates.

Anatoli B Meriin, Yan Wang, Michael Y Sherman

Abstract read
In one paragraph

Article in Current protocols in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anatoli B MeriinDepartment of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA.
Yan Wang
Michael Y Sherman

Funding

Cellular Mechanisms of Aggregation of Abnormal ProteinsR01GM086890 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHERMAN, MICHAEL Y · 2009 to 2012
$1.5M
NIGMS NIH HHS R01 GM086890
6 · The paper itself

Abstract

Upon permanent stresses and in various diseases, small protein aggregates may accumulate in cells and cause toxicity. A recently discovered protective system transports these aggregates to the centrosome location via microtubules, to form a large agglomerate of aggregates called the aggresomes. Here, we describe a newly developed method for isolating aggresomes. This principle can also be used for purification of other large structures and even organelles.

Indexed as

AnimalsBiochemistryCentrosomeHumansMicrotubule-Associated ProteinsMultiprotein ComplexesProtein MultimerizationProtein TransportMicrotubule-Associated ProteinsMultiprotein Complexes

Identifiers

PMID20853343
PMCPMC3422749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.