ArticleSurgical and radiologic anatomy : SRA2011
Contribution of the anterior longitudinal ligament to ossification and growth of the vertebral body: an immunohistochemical study using the human fetal lumbar vertebrae.
Article in Surgical and radiologic anatomy : SRA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Insights into the Pathophysiology of Scheuermann's Kyphosis: From Structural Deformities to Genetic Predisposition and Underlying Signalling Pathways.Biomolecules · 2025Review
- Neural-Dural Transition at the Thoracic and Lumbar Spinal Nerve Roots: A Histological Study of Human Late-Stage Fetuses.BioMed research international · 2016Article
- Morphometric study of the T6 vertebra and its three ossification centers in the human fetus.Surgical and radiologic anatomy : SRA · 2013Article
- Cross-sectional study of the neural ossification centers of vertebrae C1-S5 in the human fetus.Surgical and radiologic anatomy : SRA · 2013Article
- Cross-sectional study of the ossification center of the C1-S5 vertebral bodies.Surgical and radiologic anatomy : SRA · 2013Article
- Heterogeneity of glandular cells in the human salivary glands: an immunohistochemical study using elderly adult and fetal specimens.Anatomy & cell biology · 2013Article
- New anatomical data on the growing C4 vertebra and its three ossification centers in human fetuses.Surgical and radiologic anatomy : SRA · 2013Article
- Dense distribution of macrophages in flexor aspects of the hand and foot of mid-term human fetuses.Anatomy & cell biology · 2012Article
- The anatomy of fetal peripheral lymphatic vessels in the head-and-neck region: an immunohistochemical study.Journal of anatomy · 2012Article
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7 authors.
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Abstract
Using 15 mid-term human fetuses, we examined the role of the spine anterior and posterior longitudinal ligaments (ALL, PLL) in ossification of the lumbar vertebral body. By 18 weeks, a pair of calcified tissue or cortical walls had developed on the anterior and posterior sides of the ossification center. These calcified cortical walls were more highly eosinophilic than trabecular or woven bone in the ossification center. Vimentin-positive osteoblasts were arranged in line along the outer surface of the walls. However, few CD68-positive osteoclasts were evident around the walls, suggesting that the calcification in the walls was similar to periosteal ossification. The anterior cortical wall was connected tightly with the ALL by fiber bundles, but the posterior wall was separated from the PLL by the basivertebral (central) vein and loose tissues. Notably, by 30 weeks, the anterior cortical wall had become attached to and incorporated into the ALL. Thus, the ALL seemed to act as an active periosteum for ossification. Although our materials were limited in number and stage, we hypothesized that, in contrast to the PLL, the mature anterior cortical wall corresponds to a calcified fibrocartilage adjacent to the ALL and forms a bone-ligament interface maintaining an ossification potential.
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