ArticleGenes & cancer2010
The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis.
Article in Genes & cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The role of zyxin in signal transduction and its relationship with diseases.Frontiers in molecular biosciences · 2024Review
- Zyxin inhibits the epithelial-mesenchymal transition process in gastric cancer by upregulating SIRT1.MedComm · 2023Article
- Discoidin domain receptor-2 enhances secondary alveolar septation in mice by activating integrins and modifying focal adhesions.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study.Biomolecules · 2022Article
- Multiplexed labeling of cellular proteins with split fluorescent protein tags.Communications biology · 2021Article
- Discovery of Novel Markers for Identifying Cognitive Decline Using Neuron-Derived Exosomes.Frontiers in aging neuroscience · 2021Article
- Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival.Cell death & disease · 2020Article
- Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy.The Journal of biological chemistry · 2020Article
- The role of zyxin in regulation of malignancies.Heliyon · 2018Review
- Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- PTHrP attenuates osteoblast cell death and apoptosis induced by a novel class of anti-cancer agents.Endocrine · 2016Article
- Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells.Journal of the American Heart Association · 2015Article
- Review
- Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.Molecular biology of the cell · 2014Article
- Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH.Biochemical and biophysical research communications · 2013Article
- ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.Molecular biology of the cell · 2013Article
- Tandem zyxin LIM sequences do not enhance force sensitive accumulation.Biochemical and biophysical research communications · 2012Article
- Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators.Molecular biology of the cell · 2012Article
- β-cell-specific gene repression: a mechanism to protect against inappropriate or maladjusted insulin secretion?Diabetes · 2012Article
- Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Zyxin is a dual-function LIM domain protein that regulates actin dynamics in response to mechanical stress and shuttles between focal adhesions and the cell nucleus. Here we show that zyxin contributes to UV-induced apoptosis. Exposure of wild-type fibroblasts to UV-C irradiation results in apoptotic cell death, whereas cells harboring a homozygous disruption of the zyxin gene display a statistically significant survival advantage. To gain insight into the molecular mechanism by which zyxin promotes apoptotic signaling, we expressed an affinity-tagged zyxin variant in zyxin-null cells and isolated zyxin-associated proteins from cell lysates under physiological conditions. A 130-kDa protein that was co-isolated with zyxin was identified by microsequence analysis as the Cell Cycle and Apoptosis Regulator Protein-1 (CARP-1). CARP-1 associates with the LIM region of zyxin. Zyxin lacking the CARP-1 binding region shows reduced proapoptotic activity in response to UV-C irradiation. We demonstrate that CARP-1 is a nuclear protein. Zyxin is modified by phosphorylation in cells exposed to UV-C irradiation, and nuclear accumulation of zyxin is induced by UV-C exposure. These findings highlight a novel mechanism for modulating the apoptotic response to UV irradiation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.