ArticleCellular & molecular immunology2010
Loss of microRNAs in thymus perturbs invariant NKT cell development and function.
Article in Cellular & molecular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.Frontiers in immunology · 2025Article
- Dynamic miRNA profile of host T cells during early hepatic stages ofFrontiers in immunology · 2022Article
- microRNA dynamic expression regulates invariant NKT cells.Cellular and molecular life sciences : CMLS · 2021Review
- Causes and Consequences of miR-150-5p Dysregulation in Myasthenia Gravis.Frontiers in immunology · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Invariant natural killer T-cell development and function with loss of microRNA-155.Immunology · 2018Article
- MicroRNA Functions in Thymic Biology: Thymic Development and Involution.Frontiers in immunology · 2018Review
- Preliminary study on decreasing the expression of FOXP3 with miR-155 to inhibit diffuse large B-cell lymphoma.Oncology letters · 2017Article
- Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.Experimental dermatology · 2017Review
- Development of invariant natural killer T cells.Current opinion in immunology · 2016Review
- Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.Nature immunology · 2015Article
- The role of microRNAs in lymphopoiesis.International journal of hematology · 2014Review
- Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Deletion of miRNAs in bone marrow prevents streptozotocin-induced murine autoimmune diabetes but deletion of miR-155 does not.Cell cycle (Georgetown, Tex.) · 2013Article
- Deletion of microRNA miR-223 increases Langerhans cell cross-presentation.The international journal of biochemistry & cell biology · 2013Article
- MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development.Critical reviews in immunology · 2013Review
- MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- miR-150 regulates the development of NK and iNKT cells.The Journal of experimental medicine · 2011Article
- MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function.Cellular & molecular immunology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
microRNAs (miRNAs) are small noncoding RNAs that mediate RNA interference to suppress protein expression at the translational level. Accumulated evidence indicates that miRNAs play critical roles in various biological processes and disease development, including autoimmune diseases. Invariant natural killer T (iNKT) cells are an unusual CD1d-restricted subset of thymus-derived T cells that are potent regulators of diverse immune responses. Our previous studies with the mouse model of bone marrow-specific Dicer deletion suggest the involvement of Dicer-dependent miRNAs in the development and function of iNKT cells. In the present study, to further dissect the functional levels of Dicer-dependent miRNAs in regulating iNKT cell development, we generated a mouse model with the Dicer deletion in the thymus. Our data indicate that lack of miRNAs following the deletion of Dicer in the thymus severely interrupted the development and maturation of iNKT cells in the thymus and significantly decreased the number of iNKT cells in the peripheral immune organs. miRNA-deficient peripheral iNKT cells display profound defects in activation and cytokine production upon α-galactosylceramide (α-GalCer) stimulation. Our results demonstrate a critical role of the miRNA-dependent pathway in the thymus in the regulation of iNKT cell development and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.