ArticleNature cell biology2010
Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.
Article in Nature cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Coordinated single-nucleus responses for quantitative disease resistance involve a calcium-associated switch in transcriptional noise.Genome biology · 2025Article
- Reshaping the yeast galactose regulon via GPCR signaling cascade.Cell reports methods · 2023Article
- Review
- Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission.Nature communications · 2020Article
- Quantitative analysis of the yeast pheromone pathway.Yeast (Chichester, England) · 2019Article
- Article
- Intratumoral Heterogeneity: More Than Just Mutations.Trends in cell biology · 2019Review
- Communicate and Fuse: How Filamentous Fungi Establish and Maintain an Interconnected Mycelial Network.Frontiers in microbiology · 2019Review
- Multiple transcription factors contribute to inter-chromosomal interaction in yeast.BMC systems biology · 2018Article
- Article
- Timing of gene expression in a cell-fate decision system.Molecular systems biology · 2018Article
- Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling.Molecular systems biology · 2018Article
- Locus-specific ChIP combined with NGS analysis reveals genomic regulatory regions that physically interact with the Pax5 promoter in a chicken B cell line.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Pervasive coexpression of spatially proximal genes is buffered at the protein level.Molecular systems biology · 2017Article
- Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast.ACS synthetic biology · 2017Article
- HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site.Journal of virology · 2016Article
- Spatially coordinated replication and minimization of expression noise constrain three-dimensional organization of yeast genome.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Strategies to regulate transcription factor-mediated gene positioning and interchromosomal clustering at the nuclear periphery.The Journal of cell biology · 2016Article
- Biochemical Analysis of Genome Functions Using Locus-Specific Chromatin Immunoprecipitation Technologies.Gene regulation and systems biology · 2016Review
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4 authors.
Funding
Abstract
In the Saccharomyces cerevisiae pheromone-response pathway, the transcription factor Ste12 is inhibited by two mitogen-activated protein (MAP)-kinase-responsive regulators, Dig1 and Dig2. These two related proteins bind to distinct regions of Ste12 but are redundant in their inhibition of Ste12-dependent gene expression. Here we describe three functions for Dig1 that are non-redundant with those of Dig2. First, the removal of Dig1 results in a specific increase in intrinsic and extrinsic noise in the transcriptional outputs of the mating pathway. Second, in dig1Δ cells, Ste12 relocalizes from the nucleoplasmic distribution seen in wild-type cells into discrete subnuclear foci. Third, genome-wide insertional chromatin immunoprecipitation studies revealed that Ste12-dependent genes have increased interchromosomal interactions in dig1Δ cells. These findings suggest that the regulation of gene expression through long-range gene interactions, a widely observed phenomenon, comes at the cost of increased noise. Consequently, cells may have evolved mechanisms to suppress noise by controlling these interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.