ArticleNature chemical biology2010
Messy biology and the origins of evolutionary innovations.
Article in Nature chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
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- Spatial Visualization of Secreted Lysyl Oxidase Activity from Single Living Cells via Label-Free Electrochemiluminescence Microscopy.Chemical & biomedical imaging · 2026Article
- Recent Applications of Albumin as a Green and Versatile Catalyst in Organic Synthesis.Molecules (Basel, Switzerland) · 2025Review
- Effect of Mutations on the Evolution of Extended Spectrum β-lactamases (ESBL).The protein journal · 2025Review
- Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics.Nature nanotechnology · 2024Article
- The Boltzmann distributions of molecular structures predict likely changes through random mutations.Biophysical journal · 2023Article
- The non-deterministic genotype-phenotype map of RNA secondary structure.Journal of the Royal Society, Interface · 2023Article
- Article
- Intrinsic protein disorder uncouples affinity from binding specificity.Protein science : a publication of the Protein Society · 2022Article
- Phenotypic mutations contribute to protein diversity and shape protein evolution.Protein science : a publication of the Protein Society · 2022Review
- Mechanisms of protein evolution.Protein science : a publication of the Protein Society · 2022Review
- The origin of RNA interference: Adaptive or neutral evolution?PLoS biology · 2022Article
- Information Fragmentation, Encryption and Information Flow in Complex Biological Networks.Entropy (Basel, Switzerland) · 2022Article
- The Moderately (D)efficient Enzyme: Catalysis-Related DamageBiochemistry · 2021Article
- Picking the right metaphors for addressing microbial systems: economic theory helps understanding biological complexity.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Soil chemistry determines whether defensive plant secondary metabolites promote or suppress herbivore growth.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Arginine Modulates Carbapenem Deactivation by OXA-24/40 in Acinetobacter baumannii.Journal of molecular biology · 2021Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological messiness relates to infidelity, heterogeneity, stochastic noise and variation--both genetic and phenotypic--at all levels, from single proteins to organisms. Messiness comes from the complexity and evolutionary history of biological systems and from the high cost of accuracy. For better or for worse, messiness is inherent to biology. It also provides the raw material for physiological and evolutionary adaptations to new challenges.
Indexed as
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20852602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.