ArticleThe Plant cell2010
The Chlorella variabilis NC64A genome reveals adaptation to photosymbiosis, coevolution with viruses, and cryptic sex.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
206 citing papers in PubMed, 498 citations in OpenAlex.
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- A Simple Protocol for Periodic Live Cell Observation of Flagellate Stages in the Lichen AlgaBio-protocol · 2026Article
- Cross-species dissection of saline-related genes by genetically deciphering a euryhaline microalga Chlorella sp.Nature communications · 2026Article
- Exploring the digestive processes of symbiotic Chlorella sp. in non-endosymbiotic Paramecium species, Paramecium multimicronucleatum.Protoplasma · 2026Article
- Targeted genetic manipulation and yeast-like evolutionary genomics in the green alga Auxenochlorella.The Plant cell · 2025Article
- Genomic Analysis of Carotenoid and Vitamin E Biosynthetic Pathways in the Extremophilic Red AlgaAntioxidants (Basel, Switzerland) · 2025Article
- Targeted genetic manipulation and yeast-like evolutionary genomics in the green algabioRxiv : the preprint server for biology · 2025Article
- Knock Down ofPlants (Basel, Switzerland) · 2025Article
- Zoospore diversity and sexual reproduction in the lichen-forming genus Trebouxia: From neglected evidence to new facts.Plant biology (Stuttgart, Germany) · 2025Article
- Fermentation of Microalgae as a Platform for Naturally Encapsulated Oil Powders: Characterization of a High-Oleic Algal Powder Ingredient.Microorganisms · 2025Article
- The cell biology and genome ofMolecular biology of the cell · 2025Article
- Phylogenetic Analysis, Pulse-Amplitude-Modulated (PAM) Fluorometry Measuring Parameter Optimization, and Cell Wall Disintegration ofMicroorganisms · 2025Article
- Genomic Signatures of Adaptation to Stress Reveal Shared Evolutionary Trends Between Tetrahymena utriculariae and Its Algal Endosymbiont, Micractinium tetrahymenae.Molecular biology and evolution · 2025Article
- Comparative genomics and evolutionary analyses of Sphaeropleales.Frontiers in plant science · 2025Article
- AlgaeOrtho, a bioinformatics tool for processing ortholog inference results in algae.Frontiers in microbiology · 2025Article
- Biological and Nutritional Applications of Microalgae.Nutrients · 2024Review
- Effects of the SymbioticMicroorganisms · 2024Review
- Conserved carotenoid pigmentation in reproductive organs of Charophyceae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
146 more citing papers are in PubMed but not listed here.
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17 authors at 7 institutions in 3 countries.
Funding
Abstract
Chlorella variabilis NC64A, a unicellular photosynthetic green alga (Trebouxiophyceae), is an intracellular photobiont of Paramecium bursaria and a model system for studying virus/algal interactions. We sequenced its 46-Mb nuclear genome, revealing an expansion of protein families that could have participated in adaptation to symbiosis. NC64A exhibits variations in GC content across its genome that correlate with global expression level, average intron size, and codon usage bias. Although Chlorella species have been assumed to be asexual and nonmotile, the NC64A genome encodes all the known meiosis-specific proteins and a subset of proteins found in flagella. We hypothesize that Chlorella might have retained a flagella-derived structure that could be involved in sexual reproduction. Furthermore, a survey of phytohormone pathways in chlorophyte algae identified algal orthologs of Arabidopsis thaliana genes involved in hormone biosynthesis and signaling, suggesting that these functions were established prior to the evolution of land plants. We show that the ability of Chlorella to produce chitinous cell walls likely resulted from the capture of metabolic genes by horizontal gene transfer from algal viruses, prokaryotes, or fungi. Analysis of the NC64A genome substantially advances our understanding of the green lineage evolution, including the genomic interplay with viruses and symbiosis between eukaryotes.
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