ArticleApplied and environmental microbiology2010
Activation of two different resistance mechanisms in Saccharomyces cerevisiae upon exposure to octanoic and decanoic acids.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 85 citations in OpenAlex.
- Extracellular Metabolites fromMicroorganisms · 2026Article
- Dimorphism of oleaginous yeast Meyerozyma guilliermondii during single-cell oil production under decanoic acid stress.World journal of microbiology & biotechnology · 2026Article
- Engineering yeast for tailored fatty acid profiles.Applied microbiology and biotechnology · 2025Review
- Understanding brewing trait inheritance inmSystems · 2024Article
- Optimizing hexanoic acid biosynthesis in Saccharomyces cerevisiae for the de novo production of olivetolic acid.Biotechnology for biofuels and bioproducts · 2024Article
- Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids.Microbial cell factories · 2024Article
- A transcriptomic atlas of acute stress response to low pH in multipleMicrobiology spectrum · 2024Article
- Mediator Engineering ofApplied and environmental microbiology · 2022Article
- Transcriptomic response of Saccharomyces cerevisiae to octanoic acid production.FEMS yeast research · 2021Article
- Engineering carboxylic acid reductase for selective synthesis of medium-chain fatty alcohols in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Discovery and identification of medium-chain fatty acid responsive promoters inEngineering in life sciences · 2020Article
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- Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1-regulated multidrug/multixenobiotic resistance transporter Tpo1.Applied microbiology and biotechnology · 2017Article
- Post-translocational adaptation drives evolution through genetic selection and transcriptional shift in Saccharomyces cerevisiae.Current genetics · 2017Article
- Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.International journal for parasitology. Drugs and drug resistance · 2016Article
- Lager yeast comes of age.Eukaryotic cell · 2014Review
- Transcriptome of Saccharomyces cerevisiae during production of D-xylonate.BMC genomics · 2014Article
- Differential adaptation to multi-stressed conditions of wine fermentation revealed by variations in yeast regulatory networks.BMC genomics · 2013Article
- Understanding biocatalyst inhibition by carboxylic acids.Frontiers in microbiology · 2013Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medium-chain fatty acids (octanoic and decanoic acids) are well known as fermentation inhibitors. During must fermentation, the toxicity of these fatty acids is enhanced by ethanol and low pH, which favors their entrance in the cell, resulting in a decrease of internal pH. We present here the characterization of the mechanisms involved in the establishment of the resistance to these fatty acids. The analysis of the transcriptome response to the exposure to octanoic and decanoic acids revealed that two partially overlapping mechanisms are activated; both responses share many genes with an oxidative stress response, but some key genes were activated differentially. The transcriptome response to octanoic acid stress can be described mainly as a weak acid response, and it involves Pdr12p as the main transporter. The phenotypic analysis of knocked-out strains confirmed the role of the Pdr12p transporter under the control of WAR1 but also revealed the involvement of the Tpo1p major facilitator superfamily proteins (MFS) transporter in octanoic acid expulsion. In contrast, the resistance to decanoic acid is composite. It also involves the transporter Tpo1p and includes the activation of several genes of the beta-oxidation pathway and ethyl ester synthesis. Indeed, the induction of FAA1 and EEB1, coding for a long-chain fatty acyl coenzyme A synthetase and an alcohol acyltransferase, respectively, suggests a detoxification pathway through the production of decanoate ethyl ester. These results are confirmed by the sensitivity of strains bearing deletions for the transcription factors encoded by PDR1, STB5, OAF1, and PIP2 genes.
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