ArticleThe Journal of biological chemistry2010
Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- FGFRL1: Structure, Molecular Function, and Involvement in Human Disease.Current issues in molecular biology · 2025Review
- Article
- No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1.Science advances · 2024Article
- Germline and Somatic Cell Syncytia in Insects.Results and problems in cell differentiation · 2024Review
- Aberrant Expression of FGFRL1 in Esophageal Cancer and Its Regulation by miR-107.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility.Bioengineered · 2021Article
- Dissecting the Interaction of FGF8 with Receptor FGFRL1.Biomolecules · 2020Article
- [Expression of fibroblast growth factor receptor like 1 protein in oral squamous cell carcinoma and its influence on tumor cell proliferation and migration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Article
- Inhibition of c-Myc expression accounts for an increase in the number of multinucleated cells in human cervical epithelial cells.Oncology letters · 2017Article
- Receptor FGFRL1 acts as a tumor suppressor in nude mice when overexpressed in HEK 293 Tet-On cells.Oncology letters · 2016Article
- Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion.International journal of molecular medicine · 2016Article
- Article
- Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1.International journal of molecular medicine · 2013Article
- Role of FGFRL1 and other FGF signaling proteins in early kidney development.Cellular and molecular life sciences : CMLS · 2013Review
- A net-like structure with pores is observed during cell fusion induced by the receptor FGFRL1.Communicative & integrative biology · 2011Article
- Biology of FGFRL1, the fifth fibroblast growth factor receptor.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fusion of mammalian cells into syncytia is a developmental process that is tightly restricted to a limited subset of cells. Besides gamete and placental trophoblast fusion, only macrophages and myogenic stem cells fuse into multinucleated syncytia. In contrast to viral cell fusion, which is mediated by fusogenic glycoproteins that actively merge membranes, mammalian cell fusion is poorly understood at the molecular level. A variety of mammalian transmembrane proteins, among them many of the immunoglobulin superfamily, have been implicated in cell-cell fusion, but none has been shown to actively fuse cells in vitro. Here we report that the FGFRL1 receptor, which is up-regulated during the differentiation of myoblasts into myotubes, fuses cultured cells into large, multinucleated syncytia. We used luciferase and GFP-based reporter assays to confirm cytoplasmic mixing and to identify the fusion inducing domain of FGFRL1. These assays revealed that Ig-like domain III and the transmembrane domain are both necessary and sufficient to rapidly fuse CHO cells into multinucleated syncytia comprising several hundred nuclei. Moreover, FGFRL1 also fused HEK293 and HeLa cells with untransfected CHO cells. Our data show that FGFRL1 is the first mammalian protein that is capable of inducing syncytium formation of heterologous cells in vitro.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.