Evidence map›Paper›PMID 20851695›Full record

ReviewMolecular oncology2010

Targeted nanoagents for the detection of cancers.

Jason R McCarthy, Jayeeta Bhaumik, Mark R Karver, S Sibel Erdem, Ralph Weissleder

Abstract readReview
In one paragraph

Review in Molecular oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma.American journal of nuclear medicine and molecular imaging · 2022
    Review
  3. Chitosan overlaid FeScientific reports · 2020
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Targeted Magnetic Nanotheranostics of Cancer.Molecules (Basel, Switzerland) · 2017
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Comparison of tumor neovasculature-targeted paramagnetic nanoliposomes for MRI in mice xenograft models.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014
    Article
  14. Article
  15. Review
  16. Effect of magnetic nanoparticles on tobacco BY-2 cell suspension culture.International journal of environmental research and public health · 2012
    Article
  17. Article
  18. Article
  19. The role of nanomedicine in cell based therapeutics in cancer and inflammation.International journal of molecular and cellular medicine · 2012
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason R McCarthyCenter for Systems Biology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA. jason_mccarthy@hms.harvard.edu
Jayeeta Bhaumik
Mark R Karver
S Sibel Erdem
Ralph Weissleder

Funding

Translational Program of Excellence in NanotechnologyU01HL080731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2005 to 2009
$14.9M
Multimodal nanoagents for the detection and treatment of atherosclerosisR21HL093607 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MCCARTHY, JASON R. · 2009 to 2010
$486k
NHLBI NIH HHS R21 HL093607NHLBI NIH HHS R21HL093607NHLBI NIH HHS U01 HL080731NHLBI NIH HHS U01-HL080731
6 · The paper itself

Abstract

Nanotechnology has enabled a renaissance in the diagnosis of cancers. This is due, in part to the ability to develop agents bearing multiple functionalities, including those utilized for targeting, imaging, and therapy, allowing for the tailoring of the properties of the nanomaterials. Whereas many nanomaterials exhibit localization to diseased tissues via intrinsic targeting, the addition of targeting ligands, such as antibodies, peptides, aptamers, and small molecules, facilitates far more sensitive cancer detection. As such, this review focuses upon some of the most poignant examples of the utility of affinity ligand targeted nanoagents in the detection of cancer.

Indexed as

NanostructuresAnimalsAptamers, PeptideDrug Delivery SystemsFluorescent DyesHumansImaging, Three-DimensionalLigandsMolecular StructureNeoplasmsPeptidesAptamers, PeptideFluorescent DyesLigandsPeptides

Identifiers

PMID20851695
PMCPMC2981649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.