Evidence map›Paper›PMID 20851595›Full record

ReviewCurrent opinion in genetics & development2010

Frequency control of cell cycle oscillators.

Catherine Oikonomou, Frederick R Cross

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Catherine OikonomouThe Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Frederick R Cross

Funding

Stochastic Models of Cell Cycle Regulation in EukaryotesR01GM078989 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI PECCOUD, JEAN M, TYSON, JOHN J. · 2006 to 2018
$5.3M
SPECIFICITY OF CYCLIN FUNCTION AT CELL CYCLE INITIATIONR01GM047238 · NIGMS · ROCKEFELLER UNIVERSITY · PI CROSS, FREDERICK R. · 1993 to 2010
$3.4M
Sources and Consequences of noise in cell cycle regulationR01GM078153 · NIGMS · ROCKEFELLER UNIVERSITY · PI CROSS, FREDERICK R. · 2006 to 2019
$3.3M
Experimental and Computational Studies of Exit from Mitosis in Budding YeastR01GM079207 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TYSON, JOHN J. · 2007 to 2010
$1.5M
NIGMS NIH HHS R01 GM047238NIGMS NIH HHS R01 GM078153NIGMS NIH HHS R01 GM078989NIGMS NIH HHS R01 GM079207
6 · The paper itself

Abstract

The cell cycle oscillator, based on a core negative feedback loop and modified extensively by positive feedback, cycles with a frequency that is regulated by environmental and developmental programs to encompass a wide range of cell cycle times. We discuss how positive feedback allows frequency tuning, how size and morphogenetic checkpoints regulate oscillator frequency, and how extrinsic oscillators such as the circadian clock gate cell cycle frequency. The master cell cycle regulatory oscillator in turn controls the frequency of peripheral oscillators controlling essential events. A recently proposed phase-locking model accounts for this coupling.

Indexed as

Cell CycleCircadian ClocksAnimalsGene Expression RegulationHumansModels, Biological

Identifiers

PMID20851595
PMCPMC3522487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.