ReviewBrain research2010
The transcriptional control of female puberty.
Review in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The association between pubertal timing and diurnal cortisol activity in middle adolescence.Stress (Amsterdam, Netherlands) · 2026Article
- Multi-trait GWAS of reaction norm parameters reveals environment-responsive loci influencing reproductive performance in heifers.Journal of animal science and biotechnology · 2026Article
- Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing.Current issues in molecular biology · 2025Review
- Grid1 regulates the onset of puberty in female rats.The Journal of veterinary medical science · 2024Article
- Adult height in girls with idiopathic central precocious puberty treated with triptorelin.Frontiers in endocrinology · 2024Observational
- Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis.International journal of molecular sciences · 2021Review
- Characterization of Genome-Wide DNA Methylation and Hydroxymethylation in Mouse Arcuate Nucleus of Hypothalamus During Puberty Process.Frontiers in genetics · 2020Article
- EAP1 regulation of GnRH promoter activity is important for human pubertal timing.Human molecular genetics · 2019Article
- RNA-seq analysis of lncRNA-controlled developmental gene expression during puberty in goat & rat.BMC genetics · 2018Article
- Identification of differential genomic DNA Methylation in the hypothalamus of pubertal rat using reduced representation Bisulfite sequencing.Reproductive biology and endocrinology : RB&E · 2017Article
- Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12.Autophagy · 2017Article
- Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health.Developmental psychobiology · 2015Review
- Cell Type-Specific Sexual Dimorphism in Rat Pituitary Gene Expression During Maturation.Biology of reproduction · 2015Article
- Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.Molecular and cellular endocrinology · 2015Article
- Article
- Treatment of children and adolescents with idiopathic short stature.Nature reviews. Endocrinology · 2013Review
- Epigenetic control of female puberty.Nature neuroscience · 2013Article
- Applying gene silencing technology to contraception.Reproduction in domestic animals = Zuchthygiene · 2012Article
- Targeted gene silencing to induce permanent sterility.Reproduction in domestic animals = Zuchthygiene · 2012Article
- Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.Biology of reproduction · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The initiation of mammalian puberty requires a sustained increase in pulsatile release of gonadotrophin releasing hormone (GnRH) from the hypothalamus. This increase is brought about by coordinated changes in transsynaptic and glial-neuronal communication, consisting of an increase in neuronal and glial stimulatory inputs to the GnRH neuronal network and the loss of transsynaptic inhibitory influences. GnRH secretion is stimulated by transsynaptic inputs provided by excitatory amino acids (glutamate) and at least one peptide (kisspeptin), and by glial inputs provided by growth factors and small bioactive molecules. The inhibitory input to GnRH neurons is mostly transsynaptic and provided by GABAergic and opiatergic neurons; however, GABA has also been shown to directly excite GnRH neurons. There are many genes involved in the control of these cellular networks, and hence in the control of the pubertal process as a whole. Our laboratory has proposed the concept that these genes are arranged in overlapping networks internally organized in a hierarchical fashion. According to this concept, the highest level of intra-network control is provided by transcriptional regulators that, by directing expression of key subordinate genes, impose genetic coordination to the neuronal and glial subsets involved in initiating the pubertal process. More recently, we have begun to explore the concept that a more dynamic and encompassing level of integrative coordination is provided by epigenetic mechanisms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.