ArticleThe Journal of urology2010
Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats.
Article in The Journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of different diets used to induce obesity/metabolic syndrome on bladder function in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction-A Novel Hypothesis.Frontiers in surgery · 2018Article
- Path of translational discovery of urological complications of obesity and diabetes.American journal of physiology. Renal physiology · 2017Review
- Bladder function in mice with inducible smooth muscle-specific deletion of the manganese superoxide dismutase gene.American journal of physiology. Cell physiology · 2015Article
- Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes.The Journal of urology · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeUrinary diversion has been used as a surgical option for some bladder diseases. We developed a urinary diversion model in the rat and examined the effects of urinary diversion on the bladder. MATERIALS AND
methodsWe distributed female Sprague-Dawley® rats into age matched control, sham urinary diversion and urinary diversion groups. Each group was subsequently evaluated 1 or 8 weeks after urinary diversion or sham operation. Diversion was done by surgical disconnection of the ureters from the bladder and implantation to the uterine cervix. Conscious cystometry was examined. Bladders were harvested for histological examination and quantification of smooth muscle, urothelium and collagen. Vaginal histology was assessed. Bladder muscarinic and purinergic receptor expression was examined.
resultsAll rats survived the urinary diversion procedure. Bladder weight decreased in the diversion group. Cystometry showed decreased intercontractile interval and voided volume in the urinary diversion group compared to those in the control and sham operated groups. Compliance was decreased in diverted rats. Smooth muscle and urothelium were decreased as a percent of total bladder cross-sectional area. Collagen increased in 1 and 8-week diverted rats vs controls. Histological examination of the vaginal wall revealed mild swelling in 2 rats. Urinary diversion caused decreased muscarinic 3 and ligand gated purinergic 1 receptor expression but no change in muscarinic 2 or ligand gated purinergic 2 receptors.
conclusionsCreating a urinary diversion model by ureterovaginostomy in the rat is feasible. Urinary diversion causes distinct functional and morphometric bladder alterations.
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