ReviewImmunology letters2010
TL and CD8αα: Enigmatic partners in mucosal immunity.
Review in Immunology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- The scPagwas analysis of single-cell sequencing combined with Bayesian deconvolution with SMR Reveals Tumor Heterogeneity and Predicts Immunotherapy Response in Neuroblastoma.Journal of Cancer · 2026Article
- Functional heterogeneity of γδ T cells in colorectal cancer.Frontiers in immunology · 2026Review
- Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease.Biomedicines · 2025Article
- Dynamic Changes in the Intraepithelial Lymphocyte Numbers FollowingAnimals : an open access journal from MDPI · 2024Article
- A new chromosome-scale duck genome shows a major histocompatibility complex with several expanded multigene families.BMC biology · 2024Article
- The first crystal structure of CD8αα from a cartilaginous fish.Frontiers in immunology · 2023Article
- A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.Science (New York, N.Y.) · 2022Article
- CD8ααSkin health and disease · 2021Article
- Intraepithelial T Cells Diverge by Intestinal Location as Pigs Age.Frontiers in immunology · 2020Article
- Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes.Frontiers in immunology · 2019Article
- Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier.Trends in immunology · 2018Review
- Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Innate CD8ααImmunity, inflammation and disease · 2017Article
- Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.Scientific reports · 2016Article
- CD8αα TCRαβ Intraepithelial Lymphocytes in the Mouse Gut.Digestive diseases and sciences · 2016Review
- The structural basis of chicken, swine and bovine CD8αα dimers provides insight into the co-evolution with MHC I in endotherm species.Scientific reports · 2016Article
- iCD8α cells: living at the edge of the intestinal immune system.Oncotarget · 2015Article
- CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.Immunity · 2014Article
- A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The intestinal mucosa represents a large surface area that is in contact with an immense antigenic load. The immune system associated with the intestinal mucosa needs to distinguish between innocuous food antigens, commensal microorganisms, and pathogenic microorganisms, without triggering an exaggerated immune response that may lead to excessive inflammation and/or development of inflammatory bowel disease. The thymus leukemia (TL) antigen and CD8αα are interacting surface molecules that are expressed at the frontline of the mucosal immune system: TL is expressed in intestinal epithelial cells (IEC) whereas CD8αα is expressed in lymphocytes, known as intraepithelial lymphocytes, that reside in between the IEC. In this review we discuss the significance of the interaction between TL and CD8αα in mucosal immunity during health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.