ArticlePain2010
Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice.
Article in Pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 74 citations in OpenAlex.
- Involvement of acid sensing ion channel (ASIC)-3 in an acute urinary bladder-colon cross sensitization model in rodent.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Expression of TRP Channels in Colonic Mucosa of IBS-D Patients and Its Correlation with the Severity of the Disease.Gastroenterology research and practice · 2022Article
- Spinal neuron-glia-immune interaction in cross-organ sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Pivotal Role of TRP Channels in Homeostasis and Diseases throughout the Gastrointestinal Tract.International journal of molecular sciences · 2019Review
- Optogenetic Activation of Colon Epithelium of the Mouse Produces High-Frequency Bursting in Extrinsic Colon Afferents and Engages Visceromotor Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Influence of Early Life Experience on Visceral Pain.Frontiers in systems neuroscience · 2018Review
- Ion channels, ion channel receptors, and visceral hypersensitivity in irritable bowel syndrome.Neurogastroenterology and motility · 2016Review
- Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress.Brain research · 2016Article
- TRP channel functions in the gastrointestinal tract.Seminars in immunopathology · 2016Review
- Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.CNS neuroscience & therapeutics · 2016Review
- TRPA1 in the spinal dorsal horn is involved in post-inflammatory visceral hypersensitivity: in vivo study using TNBS-treated rat model.Journal of pain research · 2016Article
- Persistent changes in peripheral and spinal nociceptive processing after early tissue injury.Experimental neurology · 2016Review
- Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Article
- Artemin Immunotherapy Is Effective in Preventing and Reversing Cystitis-Induced Bladder Hyperalgesia via TRPA1 Regulation.The journal of pain · 2015Article
- Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Article
- [Neurobiology of visceral pain].Schmerz (Berlin, Germany) · 2014Review
- Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring.Neurogastroenterology and motility · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation or pain during neonatal development can result in long-term structural and functional alterations of nociceptive pathways, ultimately altering pain perception in adulthood. We have developed a mouse model of neonatal colon irritation (NCI) to investigate the plasticity of pain processing within the viscerosensory system. Mouse pups received an intracolonic administration of 2% mustard oil (MO) on postnatal days 8 and 10. Distal colons were processed at subsequent timepoints for myeloperoxidase (MPO) activity and growth factor expression. Adult mice were assessed for visceral hypersensitivity by measuring the visceromotor response during colorectal distension. Dorsal root ganglion (DRG) neurons from adult mice were retrogradely labeled from the distal colon and calcium imaging was used to measure transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) responses to acute application of capsaicin and MO, respectively. Despite the absence of inflammation (as indicated by MPO activity), neonatal exposure to intracolonic MO transiently maintained a higher expression level of growth factor messenger RNA (mRNA). Adult NCI mice displayed significant visceral hypersensitivity, as well as increased sensitivity to mechanical stimulation of the hindpaw, compared to control mice. The percentage of TRPA1-expressing colon afferents was significantly increased in NCI mice, however they displayed no increase in the percentage of TRPV1-immunopositive or capsaicin-sensitive colon DRG neurons. These results suggest that early neonatal colon injury results in a long-lasting visceral hypersensitivity, possibly driven by an early increase in growth factor expression and maintained by permanent changes in TRPA1 function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.