Evidence map›Paper›PMID 20850185›Full record

ArticlePsychiatry research2011

Psychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictions.

Roope Tikkanen, Laura Auvinen-Lintunen, Francesca Ducci, Rickard L Sjöberg, David Goldman, Jari Tiihonen, Ilkka Ojansuu, Matti Virkkunen

Abstract read
In one paragraph

Article in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  12. Dopamine Genetics and Function in Food and Substance Abuse.Journal of genetic syndromes & gene therapy · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Roope TikkanenInstitute of Clinical Medicine, Department of Psychiatry, University of Helsinki, Finland. roop.tikkanen@helsiki.fi
Laura Auvinen-Lintunen
Francesca Ducci
Rickard L Sjöberg
David Goldman
Jari Tiihonen
Ilkka Ojansuu
Matti Virkkunen
University of Helsinki · FIFinnish Institute for Health and Welfare · FIHelsinki Art Museum · FINational Institute on Alcohol Abuse and Alcoholism · USUniversity Hospital of Umeå · SE

Funding

Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
Gene-Environment Interations Underlying Alcoholism Vulnerability DisordersZIAAA000306 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2016
$839k
Gene-Environment Interations Underlying Alcoholism Vulnerability DisordersZ01AA000306 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2006 to 2008
$122k
Intramural NIH HHS Z01 AA000306
6 · The paper itself

Abstract

The Revised Psychopathy Checklist (PCL-R) has shown a moderate association with violence. The efficacy of PCL-R in varying monoamine oxidase A (MAOA) genotypes is, however, unexamined. The aim of this study was to investigate the effect of PCL-R and psychopathy on the risk for violent reconvictions among 167 MAOA genotyped alcoholic offenders. Violent reconvictions and PCL-R scores among violent offenders were assessed after a 7-year non-incarcerated follow-up. Regression analysis was used to evaluate the alcohol exposure and age-adjusted effect of PCL-R score and psychopathy on the risk for reconvictions among differing MAOA genotypes. Results suggest that the PCL-R total score predicts impulsive reconvictions among high-activity MAOA offenders (6.8% risk increase for every one-point increase in PCL-R total score, P = 0.015), but not among low-activity MAOA offenders, whereas antisocial behavior and attitudes predicted reconvictions in both genotypes (17% risk increase among high-activity MAOA offenders and 12.8% increase among low-activity MAOA offenders for every one-point increase in factor 2 score). Both narcissistic self-image with related interpersonal style (factor 1 score) and psychopathy (PCL-R ≥ 30) failed to predict future violence. Results suggest that the efficacy of PCL-R is altered by MAOA genotype, alcohol exposure, and age, which seems important to note when PCL-R is used for risk assessments that will have legal or costly preventive work consequences.

Indexed as

PsychopathologyAdultAlcoholismAntisocial Personality DisorderChecklistFinlandGenotypeHumansLongitudinal StudiesMaleMonoamine OxidasePolymorphism, GeneticPredictive Value of TestsPsychiatric Status Rating ScalesRetrospective StudiesViolenceMonoamine Oxidase

Identifiers

PMID20850185
PMCPMC3506166
OpenAlexW2129090500

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.