ArticleBMC chemical biology2010
The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds.
Article in BMC chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides.Molecular cancer therapeutics · 2024Review
- Mitogenome Characterization of FourInternational journal of molecular sciences · 2023Article
- Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals.Marine drugs · 2023Review
- High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development.Biodesign research · 2022Article
- A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails.Proceedings. Biological sciences · 2021Article
- Article
- Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity.Scientific reports · 2018Article
- Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.Marine drugs · 2018Review
- Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails.Integrative and comparative biology · 2016Article
- Review
- Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra guttata.Toxins · 2016Article
- Developing a Dissociative Nanocontainer for Peptide Drug Delivery.International journal of environmental research and public health · 2015Article
- Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers.Scientific reports · 2015Article
- Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails.Genome biology and evolution · 2015Article
- One, four or 100 genera? A new classification of the cone snails.The Journal of molluscan studies · 2015Article
- Review
- Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors.Toxins · 2013Article
- Molecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analyses.PloS one · 2013Article
- Macroevolution of venom apparatus innovations in auger snails (Gastropoda; Conoidea; Terebridae).Molecular phylogenetics and evolution · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The Conoidea superfamily, comprised of cone snails, terebrids, and turrids, is an exceptionally promising group for the discovery of natural peptide toxins. The potential of conoidean toxins has been realized with the distribution of the first Conus (cone snail) drug, Prialt (ziconotide), an analgesic used to alleviate chronic pain in HIV and cancer patients. Cone snail toxins (conotoxins) are highly variable, a consequence of a high mutation rate associated to duplication events and positive selection. As Conus and terebrids diverged in the early Paleocene, the toxins from terebrids (teretoxins) may demonstrate highly divergent and unique functionalities. Recent analyses of the Terebridae, a largely distributed family with more than 300 described species, indicate they have evolutionary and pharmacological potential. Based on a three gene (COI, 12S and 16S) molecular phylogeny, including ~50 species from the West-Pacific, five main terebrid lineages were discriminated: two of these lineages independently lost their venom apparatus, and one venomous lineage was previously unknown. Knowing the phylogenetic relationships within the Terebridae aids in effectively targeting divergent lineages with novel peptide toxins. Preliminary results indicate that teretoxins are similar in structure and composition to conotoxins, suggesting teretoxins are an attractive line of research to discover and develop new therapeutics that target ion channels and receptors. Using conotoxins as a guideline, and innovative natural products discovery strategies, such as the Concerted Discovery Strategy, the potential of the Terebridae and their toxins are explored as a pioneering pharmacological resource.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.