ArticleEvoDevo2010
Conserved developmental expression of Fezf in chordates and Drosophila and the origin of the Zona Limitans Intrathalamica (ZLI) brain organizer.
Article in EvoDevo, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Resolving forebrain developmental organisation by analysis of differential growth patterns.Nature communications · 2025Article
- An ancient apical patterning system sets the position of the forebrain in chordates.Science advances · 2025Article
- The brain regulatory program predates central nervous system evolution.Scientific reports · 2023Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Gene Regulatory Networks of Epidermal and Neural Fate Choice in a Chordate.Molecular biology and evolution · 2022Article
- Hybridization Chain Reaction for Quantitative and Multiplex Imaging of Gene Expression in Amphioxus Embryos and Adult Tissues.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes.Nature communications · 2017Article
- Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain.PLoS biology · 2017Article
- Cis-regulatory architecture of a brain signaling center predates the origin of chordates.Nature genetics · 2016Article
- Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective.BMC evolutionary biology · 2016Article
- From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system.Nature reviews. Neuroscience · 2016Review
- The origin and evolution of chordate nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Embracing the comparative approach: how robust phylogenies and broader developmental sampling impacts the understanding of nervous system evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The deuterostome context of chordate origins.Nature · 2015Review
- Evolution of patterning systems and circuit elements for locomotion.Developmental cell · 2015Review
- Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain.Molecular biology and evolution · 2015Article
- Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Deep conservation of cis-regulatory elements in metazoans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Article
- The bilaterian head patterning gene six3/6 controls aboral domain development in a cnidarian.PLoS biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe zona limitans intrathalamica (ZLI) and the isthmus organizer (IsO) are two major secondary organizers of vertebrate brain development. These organizers are located at the interface of the expression domains of key patterning genes (Fezf-Irx and Otx-Gbx, respectively). To gain insights into the evolutionary origin of the ZLI, we studied Fezf in bilaterians.
resultsIn this paper, we identified a conserved sequence motif (Fezf box) in all bilaterians. We report the expression pattern of Fezf in amphioxus and Drosophila and compare it with those of Gbx, Otx and Irx. We found that the relative expression patterns of these genes in vertebrates are fully conserved in amphioxus and flies, indicating that the genetic subdivisions defining the location of both secondary organizers in early vertebrate brain development were probably present in the last common ancestor of extant bilaterians. However, in contrast to vertebrates, we found that Irx-defective flies do not show an affected Fezf expression pattern.
conclusionsThe absence of expression of the corresponding morphogens from cells at these conserved genetic boundaries in invertebrates suggests that the organizing properties might have evolved specifically in the vertebrate lineage by the recruitment of key morphogens to these conserved genetic locations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.