ArticleInflammatory bowel diseases2011
Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.
Article in Inflammatory bowel diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Mucosal Responses to Type II Interferon in IBD.Inflammatory bowel diseases · 2025Article
- Artificial Intelligence Analysis of Ulcerative Colitis Using an Autoimmune Discovery Transcriptomic Panel.Healthcare (Basel, Switzerland) · 2022Article
- Celiac disease: From genetics to epigenetics.World journal of gastroenterology · 2022Review
- New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease.Frontiers in pharmacology · 2022Review
- Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020Review
- Epigenetic regulation of T helper cells and intestinal pathogenicity.Seminars in immunopathology · 2019Review
- Comparative Effect of the I3.1 Probiotic Formula in Two Animal Models of Colitis.Probiotics and antimicrobial proteins · 2017Article
- Novel biomarkers of fibrosis in Crohn's disease.World journal of gastrointestinal pathophysiology · 2016Review
- Review
- IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer.Cancer immunology research · 2015Article
- Review
- IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.Inflammatory bowel diseases · 2014Article
- DNA methylation changes in inflammatory bowel disease.Annals of gastroenterology · 2014Review
- DNA methylation in inflammatory bowel disease and beyond.World journal of gastroenterology · 2013Review
- Article
- Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases.Inflammatory bowel diseases · 2012Article
- Interindividual variability and co-regulation of DNA methylation differ among blood cell populations.Epigenetics · 2012Article
- Epigenetics and the developmental origins of inflammatory bowel diseases.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- A functional methylome map of ulcerative colitis.Genome research · 2012Article
- Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigh antibody reactivity toward microbial antigens in Crohn's disease (CD) patients is predictive of a more aggressive disease course. However, few ulcerative colitis (UC) patients exhibit serologic reactivity toward microbial antigens. Mucosal expression of IFN-γ plays a pivotal role in inflammatory bowel disease (IBD) pathogenesis. Recent genome-wide association studies (GWAS) surprisingly link UC, but not CD, risk loci to IFNG. We recently demonstrated that mucosal T cells from IBD patients exhibit distinct patterns of IFNG methylation compared to controls. This study evaluated the relationship between IFNG methylation and serologic and clinical profiles in peripheral T cells from IBD patients.
methodsDNA from peripheral T cells of 163 IBD patients (91 CD and 64 UC) and 42 controls was analyzed for methylation of eight IFNG sites. Serum markers ASCA, OmpC, I2, CBir, and pANCA were measured by enzyme-linked immunosorbent assay (ELISA). IFN-γ secretion was measured by ELISA.
resultsIBD patients requiring surgery exhibited reduced IFNG methylation compared to nonsurgical patients (P < 0.02). Enhancement of IFN-γ secretion (P < 0.003), along with high antibody responses toward multiple microbial antigens (P < 0.017) in UC, but not CD, patients was correlated with decreased IFNG methylation. pANCA levels were not correlated with IFNG methylation.
conclusionsLevels of IFNG methylation were correlated with immune response to microbial components and expression of IFN-γ in UC patients. Serological and epigenetic markers identify a subset of UC patients with an expression profile of a key TH1 pathogenic cytokine. These data may provide a useful tool to classify a more homogeneous subset of UC patients, allowing for improved diagnostics and targeted therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.