ArticleInflammatory bowel diseases2010
Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development.
Article in Inflammatory bowel diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- The role of integrins in T cell-mediated resistance tobioRxiv : the preprint server for biology · 2026Article
- Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Colonic inflammation triggers β cell proliferation during obesity development via a liver-to-pancreas interorgan mechanism.JCI insight · 2025Article
- Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis.Journal for immunotherapy of cancer · 2023Article
- Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis.PLoS biology · 2023Article
- Effects of aging on urinary tract epithelial homeostasis and immunity.Developmental biology · 2023Review
- Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior.Journal of neuroinflammation · 2022Article
- IL-36 cytokines imprint a colitogenic phenotype on CD4Mucosal immunology · 2022Article
- Targeting Immune Cell Trafficking - Insights From Research Models and Implications for Future IBD Therapy.Frontiers in immunology · 2021Review
- Review
- The elusive case of human intraepithelial T cells in gut homeostasis and inflammation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Integrin αJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- A Review of the Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Vedolizumab.Clinical pharmacokinetics · 2017Review
- Colorectal cancer-infiltrating T lymphocytes display a distinct chemokine receptor expression profile.European journal of medical research · 2017Article
- GPR15: a tale of two species.Nature immunology · 2015Article
- Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.Nature immunology · 2015Article
- Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver.Genome biology · 2014Article
- Glutamine supplementation attenuates expressions of adhesion molecules and chemokine receptors on T cells in a murine model of acute colitis.Mediators of inflammation · 2014Article
- CD4(+) T-cell subsets in intestinal inflammation.Immunological reviews · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBlockade of the integrin α4β7 has promise as a therapy for inflammatory bowel disease. α4β7 plays diverse roles in the intestinal immune system, including lymphocyte homing and lymphoid tissue formation; however, the effects of α4β7 blockade on these processes during inflammation and their relationship to the efficacy of α4β7 blockade and its potential untoward effects are largely unknown.
methodsα4β7 function was inhibited by genetic manipulation or antibody blockade. The effects of these manipulations on lymphoid tissues and the presence of lymphocyte subpopulations in the murine small intestine and colon were evaluated in the unchallenged state, during the acute injury dextran sodium sulfate model, and during the splenocyte transfer chronic inflammation model.
resultsα4β7 inhibition resulted in a decrease in the B-lymphocyte population in the diffuse lamina propria and a decrease in the number of lymphoid aggregates in the uninflamed intestine and in the acute injury model. α4β7 blockade did not reduce the Foxp3- T-lymphocyte population but did decrease the Foxp3+ T-lymphocyte population located selectively within the lymphoid aggregates in the uninflamed intestine and in the acute injury model. In contrast, α4β7 blockade reduced the intestinal T-lymphocyte population and decreased the production of inflammatory cytokines in the T-lymphocyte mediated chronic inflammation model.
conclusionsThese findings demonstrate differential use of α4β7 by B-lymphocytes, Foxp3- T-lymphocytes, and Foxp3+ T-lymphocytes to home to the gut, and suggest that α4β7 blockade may serve as a targeted therapy that selectively inhibits the accumulation of pathogenic T-lymphocyte populations in the chronically inflamed intestine.
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Registered trials
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