ArticlePathology oncology research : POR2011
Breast cancer under 40 years of age: increasing number and worse prognosis.
Article in Pathology oncology research : POR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- HER2Ile655Val Single Nucleotide Polymorphism Associated with Early-Onset Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Diagnostic performance of the automated breast volume scanner: a systematic review of inter-rater reliability/agreement and meta-analysis of diagnostic accuracy for differentiating benign and malignant breast lesions.European radiology · 2015Pooled it
- Comparative Evaluation of Biosimilar Trastuzumab with Reference Trastuzumab Activity in HER2-Positive Breast Cancer Patients.Archives of Razi Institute · 2023Article
- Article
- Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.Biomarker insights · 2022Review
- Should women with early breast cancer under 40 years of age have a routine 21-gene recurrence score testing: A SEER database study.Breast (Edinburgh, Scotland) · 2020Article
- Risk of breast cancer based on thermal tomography characteristics.Translational cancer research · 2019Article
- An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation.Breast cancer research : BCR · 2017Article
- Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma.BMC clinical pathology · 2017Article
- Effect of Age on Breast Cancer Patient Prognoses: A Population-Based Study Using the SEER 18 Database.PloS one · 2016Article
- Pathological features of Breast Cancer seen in Northwestern Tanzania: a nine years retrospective study.BMC research notes · 2011Article
- Low frequency of HER2 amplification and overexpression in early onset gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- Breast cancer in young women: a rising threat: A 5-year follow-up comparative study.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer at a relatively young age with a poor prognosis is currently exhibiting an increasing incidence. In a retrospective cohort analysis of early breast cancer cases after surgery from our institutional patient registry, 141 patients aged ≤ 40 years constituted the younger group, with 300 randomly selected patients aged >40 years as controls. A significant and steady increase was found in the relative number of younger cases during the years 2004-2009. The histological type and grade and the lymph node status of the cancers differed significantly between the two groups, with more aggressive biological behaviour, a more advanced stage and a worse prognosis in the younger group. Half of the cancers in the younger cohort were ER-negative, while two-thirds in the control group were ER-positive. Comparatively more tumours were PR-positive and HER2-negative in the control group than in the younger group. The rates of triple-negative cases were 25% and 13% in the younger age and the control group, respectively (p = 0.026). Significantly higher mastectomy and axillary block dissection rates were observed in the younger age group, and more chemotherapy was administered than in the control group. Our findings demonstrate the significance of breast cancer in cases aged <40 years, and draw attention to the need for appropriate care in these cases.
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