ArticleMolecular biology reports2011
Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Pooled it
- Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis.BMC medical genetics · 2012Pooled it
- Association betweenNeural regeneration research · 2019Article
- The association between apolipoprotein A1-C3-A5 gene cluster promoter polymorphisms and risk of ischemic stroke in the northern Chinese Han population.The Journal of international medical research · 2017Article
- Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease.International journal of molecular sciences · 2017Review
- A meta-analysis of adiponectin gene rs22411766 T>G polymorphism and ischemic stroke susceptibility.Open medicine (Warsaw, Poland) · 2016Article
- Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents.European journal of clinical nutrition · 2015Article
- Cardiometabolic effects of adiponectin.Best practice & research. Clinical endocrinology & metabolism · 2014Review
- Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.British journal of cancer · 2013Article
- Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population.Journal of molecular neuroscience : MN · 2012Article
- Polymorphism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population: relation with insulin resistance and response to treatment with pioglitazone in patients with type 2 diabetes mellitus.Molecular biology reports · 2012Article
- Association of +45(T/G) and +276(G/T) polymorphisms in the adiponectin gene with coronary artery disease in a population of Iranian patients with type 2 diabetes.Molecular biology reports · 2012Article
- The association between adiponectin (+45T/G) and adiponectin receptor-2 (+795G/A) single nucleotide polymorphisms with cirrhosis in Iranian population.Molecular biology reports · 2012Article
- Genetic markers of cardiovascular disease in rheumatoid arthritis.Mediators of inflammation · 2012Review
- RNA interference and ischemic injury.Molecular biology reports · 2012Review
- A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population.Molecular biology reports · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin is inversely associated with the risk of ischemic stroke through its anti-inflammatory and anti-atherogenic effects. Genetic variations in the adiponectin gene (ADIPOQ) have been shown to be associated with the risk of ischemic stroke in Caucasians and Japanese populations. However, it was unknown whether variations in the ADIPOQ gene were associated with the risk of ischemic stroke in Chinese population. A case-control study was performed among 302 patients with ischemic stroke and 338 unrelated controls in a Chinese Han population. The single-nucleotide polymorphisms (SNPs) rs266729 (-11377C/G), rs2241766 (+45T/G), rs1501299 (+276G/T) in the ADIPOQ gene were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The frequencies of GG genotype and G allele of rs266729 in the patients with ischemic stroke were significantly higher than those in the controls (P = 0.034, P = 0.010, respectively). In univariate logistic analysis, compared with CC genotype, GG genotype of rs266729 increased the risk of ischemic stroke (odds ratio (OR) = 2.062, 95% confidence interval (CI) = 1.145-3.715, P = 0.016). After adjustment for potential risk factors by the multivariate logistic analysis, rs266729 remained positive correlation with ischemic stroke (OR = 2.165; 95% CI = 1.116-4.197, P = 0.022). However, no significant association was observed among rs2241766, rs1501299 and ischemic stroke. In addition, no significant difference was found in haplotype frequencies between the patients with ischemic stroke and control subjects. The present study demonstrated that the promoter polymorphism rs266729 of the ADIPOQ gene was associated with an increased risk of ischemic stroke in the Chinese Han population.
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