ReviewDigestive diseases and sciences2011
Unusual case of small cell gastric carcinoma: case report and literature review.
Review in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Retroperitoneal mixed neuroendocrine non-neuroendocrine neoplasm: A case report and review of literature.Rare tumors · 2024Article
- Article
- A case of gastric small cell carcinoma with metastases to bone and liver.Journal of gastrointestinal oncology · 2019Article
- Long-term disease free survival of gastric mixed adenoneuroendocrine carcinoma treated with multimodality therapy: A case report.Molecular and clinical oncology · 2018Article
- Collision tumor of choriocarcinoma and small cell carcinoma of the stomach: A case report.International journal of surgery case reports · 2017Article
- Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2015Review
- Management of primary gastric small cell carcinoma in China.International journal of clinical and experimental medicine · 2015Review
- Synchronous occurrence of early neuroendocrine carcinoma and tubular adenocarcinoma in the stomach.Clinical journal of gastroenterology · 2012Article
- Small cell carcinoma of gastro-oesophageal junction with remarkable response to chemo-radiotherapy.BMJ case reports · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall cell carcinomas are among the most aggressive, poorly differentiated, and highly malignant of the neuroendocrine tumors (NETs). Of which, small cell gastric carcinoma is a rare small cell neuroendocrine tumor. The purpose of our study was to present this case and perform a comprehensive literature review. METHODS AND
resultsWe review a case of small cell gastric carcinoma that is particularly unusual in that it occurred in a woman from the US when the majority of cases of small cell gastric carcinoma have been reported in men from East Asia, and more specifically, from Japan. The diagnosis was made after endoscopy revealed a large ulcerated mass in the gastric cardia of Borrmann type 3. Biopsies revealed multiple small basophilic cells underlying the squamous epithelium of the esophagus and cardiac mucosa, indicating the presence of a tumor at the gastroesophageal junction. Immunostaining established the diagnosis with positive stains for chromogranin, synaptophysin, and CD56. Our patient is being treated with chemotherapy, but many different treatment regimens have been tried for small cell gastric carcinoma with variable success.
conclusionsOverall prognosis for small cell gastric carcinoma is dismal. Neuroendocrine tumors in general have variable clinical behaviors and prognosis is dependent on the neuroendocrine tumor type. The adoption of a standardized classification system for neuroendocrine tumors could improve the recognition of infrequently encountered neuroendocrine tumors like small cell gastric carcinoma and will enhance strategies for treatment and thus improve prognosis for patients with these rare and aggressive tumors.
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