ArticlePsychopharmacology2011
Early methylphenidate exposure enhances cocaine self-administration but not cocaine-induced conditioned place preference in young adult rats.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Serotonin-dopamine interactions in psychostimulant-induced gene regulation: SSRI antidepressants potentiate gene regulation by methylphenidate (Ritalin) in the striatum and enhance behavioral profile indicative of addiction liability in rodents.Neuroscience and biobehavioral reviews · 2025Review
- Fluoxetine potentiates methylphenidate-induced behavioral responses: Enhanced locomotion or stereotypies and facilitated acquisition of cocaine self-administration.Addiction neuroscience · 2023Article
- Chronic oral methylphenidate plus fluoxetine treatment in adolescent rats increases cocaine self-administration.Addiction neuroscience · 2023Article
- Behavioral, Neurochemical and Developmental Effects of Chronic Oral Methylphenidate: A Review.Journal of personalized medicine · 2023Review
- Fluoxetine Potentiates Oral Methylphenidate-Induced Gene Regulation in the Rat Striatum.Molecular neurobiology · 2021Article
- Exposure to methylphenidate during peri-adolescence decouples the prefrontal cortex: a multimodal MRI study.American journal of translational research · 2021Article
- Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neurobehavioral changes arising from early life dopamine signaling perturbations.Neurochemistry international · 2020Review
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior.Psychopharmacology · 2019Article
- Sensitive periods of substance abuse: Early risk for the transition to dependence.Developmental cognitive neuroscience · 2017Review
- Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats.Behavioural brain research · 2016Article
- Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice.PloS one · 2016Article
- Fluoxetine exposure during adolescence increases preference for cocaine in adulthood.Scientific reports · 2015Article
- Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: potential role for 5-HT1B receptor.Neuropharmacology · 2015Article
- Article
- Potentiated gene regulation by methylphenidate plus fluoxetine treatment: Long-term gene blunting (Basal ganglia · 2014Article
- Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats.Behavioural pharmacology · 2014Article
- Selective serotonin re-uptake inhibitors potentiate gene blunting induced by repeated methylphenidate treatment: Zif268 versus Homer1a.Addiction biology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
rationalePrevious studies in rodents show that early exposure to methylphenidate alters later responsiveness to drugs of abuse. An interesting feature of these studies is that early methylphenidate treatment decreases the rewarding value of cocaine when measured by conditioned place preference (CPP), but the same treatment increases cocaine self-administration.
objectiveThe goal of the present study was to examine the effects of early methylphenidate exposure on cocaine-induced responding using both reward paradigms.
methodsRats were treated with methylphenidate (0, 2, or 5 mg/kg) from postnatal days (PDs) 11 to 20, and then cocaine-induced CPP or cocaine self-administration was measured in separate groups of rats in adulthood. The CPP procedure included 8 days of acquisition training, 8 days of extinction training, and a reinstatement test. Rats were conditioned with 0, 10, or 20 mg/kg cocaine. Reinstatement was assessed after a priming dose of cocaine (10 mg/kg). For the self-administration experiment, a jugular catheter was implanted and rats were trained to press a lever reinforced with cocaine (0.25 or 0.75 mg/kg/infusion) on a fixed ratio (FR) one schedule. Rats were gradually moved from an FR1 to an FR10 schedule and, after criterion was reached, rats were placed on a progressive ratio schedule for 5 days.
resultsCocaine produced robust rewarding effects as determined by both the CPP and self-administration experiments; however, early methylphenidate exposure only enhanced the reinforcing effects of cocaine on the self-administration paradigm. Interestingly, this methylphenidate enhancement was only seen in male rats.
conclusionsThese data suggest that in males, methylphenidate enhances the reinforcing value of cocaine, but not cocaine-associated cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.