ArticlePsychopharmacology2011
Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding.Psychopharmacology · 2026Article
- Grappling with Issues of Motherhood for Women with Schizophrenia.Healthcare (Basel, Switzerland) · 2023Review
- Positive maternal affect during mother-litter interaction is reduced in new mother rats exhibiting a depression-like phenotype.Scientific reports · 2023Article
- What can challenging reproductive contexts tell us about the rat's maternal behavior?Frontiers in behavioral neuroscience · 2023Article
- Oxytocin interactions with central dopamine and serotonin systems regulate different components of motherhood.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Decreased mesolimbic dopaminergic signaling underlies the waning of maternal caregiving across the postpartum period in rats.Psychopharmacology · 2020Article
- Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats.Psychopharmacology · 2018Article
- Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine AFrontiers in pharmacology · 2018Article
- Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.Psychopharmacology · 2016Review
- Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A₂AKO mice.Psychopharmacology · 2016Article
- Antipsychotic drugs on maternal behavior in rats.Behavioural pharmacology · 2015Review
- Early-life risperidone administration alters maternal-offspring interactions and juvenile play fighting.Pharmacology, biochemistry, and behavior · 2015Article
- Article
- Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.Molecular psychiatry · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleMesolimbic dopamine (DA), particularly in the nucleus accumbens, importantly regulates activational aspects of maternal responsiveness. DA antagonism and accumbens DA depletions interfere with early postpartum maternal motivation by selectively affecting most forms of active maternal behaviors, while leaving nursing behavior relatively intact. Considerable evidence indicates that there is a functional interaction between DA D2 and adenosine A(2A) receptors in striatal areas, including the nucleus accumbens.
objectiveThis study was conducted to determine if adenosine A(2A) receptor antagonism could reverse the effects of DA receptor antagonism on early postpartum maternal behavior.
methodsThe adenosine A(2A) receptor antagonist MSX-3 (0.25-2.0 mg/kg, IP) was investigated for its ability to reverse the effects of the DA D2 receptor antagonist haloperidol (0.1 mg/kg, IP) on the maternal behavior of early postpartum female rats.
resultsHaloperidol severely impaired the expression of active maternal components, including retrieval and grouping the pups at the nest site, pup licking, and nest building. Co-administration of MSX-3 (0.25-2.0 mg/kg, IP) with haloperidol produced a dose-related attenuation of the haloperidol-induced behavioral deficits in early postpartum females. Doses of MSX-3 that effectively reversed the effects of haloperidol (0.5, 1.0 mg/kg), when administered in the absence of haloperidol, did not affect maternal responding or locomotor activity.
conclusionsAdenosine and DA systems interact to regulate early postpartum maternal responsiveness. This research may potentially contribute to the development of strategies for treatments of psychiatric disorders during the postpartum period, with particular emphasis in maintaining or restoring the mother-infant relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.