ArticleSurgical neurology international2010
Imaging features of invasion and preoperative and postoperative tumor burden in previously untreated glioblastoma: Correlation with survival.
Article in Surgical neurology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association between medical academic genealogy and publication outcome: impact of unconscious bias on scientific objectivity.Acta neurochirurgica · 2019Pooled it
- A three-dimensional computational analysis of magnetic resonance images characterizes the biological aggressiveness in malignant brain tumours.Journal of the Royal Society, Interface · 2018Trial
- Treating the invisible target: treatment planning targeting the microscopic tumor spread in gliomas.Frontiers in oncology · 2026Article
- Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naïve glioblastoma.Neuro-oncology · 2025Article
- Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study.Neuro-oncology · 2025Article
- Risk factors and a new nomogram for glioblastoma: based on a retrospective study.Frontiers in immunology · 2025Article
- The Role of Multimodal Imaging in Differentiating Vasogenic from Infiltrative Edema: A Systematic Review.The Indian journal of radiology & imaging · 2023Review
- The impact of patient factors and tumor characteristics on language neuroplasticity in left hemispheric diffuse gliomas prior to surgical resection.Journal of neuro-oncology · 2023Article
- Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration.Frontiers in radiology · 2023Review
- Ventricular entry during surgical resection is associated with intracranial leptomeningeal dissemination in glioblastoma patients.Journal of neuro-oncology · 2022Article
- Evaluating angioarchitectural characteristics of glial and metastatic brain tumors with conventional magnetic resonance imaging.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Article
- Impact of volume of irradiation on survival and quality of life in glioblastoma: a prospective, phase 2, randomized comparison of RTOG and MDACC protocols.Neuro-oncology practice · 2020Article
- Evidence and context of use for contrast enhancement as a surrogate of disease burden and treatment response in malignant glioma.Neuro-oncology · 2018Review
- Comparison among conventional and advanced MRI,Oncotarget · 2017Article
- Impact of removed tumor volume and location on patient outcome in glioblastoma.Journal of neuro-oncology · 2017Article
- Relationship between magnetic resonance imaging characteristics and plasmatic levels of MMP2 and MMP9 in patients with recurrent high-grade gliomas treated by Bevacizumab and Irinotecan.Journal of neuro-oncology · 2017Article
- Decreased survival in glioblastomas is specific to contact with the ventricular-subventricular zone, not subgranular zone or corpus callosum.Journal of neuro-oncology · 2017Article
- Algorithmic three-dimensional analysis of tumor shape in MRI improves prognosis of survival in glioblastoma: a multi-institutional study.Journal of neuro-oncology · 2017Article
- Glioblastoma: does the pre-treatment geometry matter? A postcontrast T1 MRI-based study.European radiology · 2017Article
- Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.Neuro-oncology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA paucity of data exists concerning the prognostic usefulness of preoperative and postoperative imaging after resection of glioblastoma multiforme (GBM). This study aimed to connect outcome with imaging features of GBM.
methodsRetrospective computer-assisted volumetric calculations quantified central necrotic (T0), gadolinium-enhanced (T1) and increased T2-weighted signal volumes (T2) in 70 patients with untreated GBM. Clinical and treatment data, including extent of resection (EOR), were obtained through chart review. T1 volume was used as a measure of solid tumor burden; and T2 volume, as an indicator of invasive isolated tumor cell (ITC) burden. Indicators of invasiveness included T2:T1 ratios as a propensity for ITC infiltration compared to solid tumor volumes and qualitative analysis of subependymal growth and infiltration of the basal ganglia, corpus callosum or brainstem. Cox multivariate analysis (CMVA) was used to identify significant associations between imaging features and survival.
resultsIn the 70 patients studied, significant associations with reduced survival existed for gadolinium-enhancing tumor crossing the corpus callosum (odds ratio, 3.14) and with increased survival with gross total resection (GTR) (GTR median survival, 62 weeks versus 37 and 34 weeks for sub-total resection and biopsy, respectively). For a selected "GTR-eligible" subgroup of 52 patients, prolonged survival was associated with smaller preoperative gadolinium-enhancing volume (T1) and actual GTR.
conclusionSome magnetic resonance (MR) imaging indicators of tumor invasiveness (gadolinium-enhancing tumor crossing the corpus callosum) and tumor burden (GTR and preoperative T1 volume in GTR-eligible subgroup) correlate with survival. However, ITC-infiltrative tumor burden (T2 volume) and "propensity" for ITC invasiveness (T2:T1 ratio) did not impact survival. These results indicate that while the ITC component is the ultimate barrier to cure for GBM, the pattern of spread and volumes of gadolinium-enhancing solid tumor are more robust indicators of prognosis.
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