ArticleCirculation research2010
The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.
Article in Circulation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
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- Transcriptome analysis of human hypertrophic cardiomyopathy reveals inhibited cardiac development pathways in children.iScience · 2024Article
- Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis.International journal of molecular sciences · 2022Review
- Profiling Genome-Wide DNA Methylation Patterns in Human Aortic and Mitral Valves.Frontiers in cardiovascular medicine · 2022Article
- A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes.Frontiers in cardiovascular medicine · 2021Article
- The Role of Bmp- and Fgf Signaling Modulating Mouse Proepicardium Cell Fate.Frontiers in cell and developmental biology · 2021Article
- Biomechanical Cues Direct Valvulogenesis.Journal of cardiovascular development and disease · 2020Review
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- Disruption of FGF Signaling Ameliorates Inflammatory Response in Hepatic Stellate Cells.Frontiers in cell and developmental biology · 2020Article
- Editorial: Resident and Ectopic FGF Signaling in Development and Disease.Frontiers in cell and developmental biology · 2020Article
- Fibroblast growth factor-8 inhibits oxidative stress-induced apoptosis in H9c2 cells.Molecular and cellular biochemistry · 2017Article
- Association Between Single Nucleotide Polymorphisms in NFATC1 Signaling Pathway Genes and Susceptibility to Congenital Heart Disease in the Chinese Population.Pediatric cardiology · 2016Article
- Loss of RNA expression and allele-specific expression associated with congenital heart disease.Nature communications · 2016Article
- Wnt/β-catenin signaling enables developmental transitions during valvulogenesis.Development (Cambridge, England) · 2016Article
- Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system.The Journal of physiology · 2015Review
- Article
- The functional diversity of essential genes required for mammalian cardiac development.Genesis (New York, N.Y. : 2000) · 2014Review
- FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.Biochimica et biophysica acta · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
rationaleHeart valves develop from precursor structures called cardiac cushions, an endothelial-lined cardiac jelly that resides in the inner side of the heart tube. The cushions are then invaded by cells from different sources, undergo a series of complicated and poorly understood remodeling processes, and give rise to valves. Disruption of the fibroblast growth factor (FGF) signaling axis impairs morphogenesis of the outflow tract (OFT). Yet, whether FGF signaling regulates OFT valve formation is unknown.
objectiveTo study how OFT valve formation is regulated and how aberrant cell signaling causes valve defects. METHODS AND
resultsBy using mouse genetic manipulation, cell lineage tracing, ex vivo heart culture, and molecular biology approaches, we demonstrated that FGF signaling in the OFT myocardium upregulated Bmp4 expression, which then enhanced smooth muscle differentiation of neural crest cells (NCCs) in the cushion. FGF signaling also promoted OFT myocardial cell invasion to the cushion. Disrupting FGF signaling interrupted cushion remodeling with reduced NCCs differentiation into smooth muscle and less cardiomyocyte invasion and resulted in malformed OFT valves.
conclusionsThe results demonstrate a novel mechanism by which the FGF-BMP signaling axis regulates formation of OFT valve primordia by controlling smooth muscle differentiation of cushion NCCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.