ArticleThe American journal of pathology2010
Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Reelin Signaling and Synaptic Plasticity in Schizophrenia.Brain sciences · 2023Review
- Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell receptor sequencing.Molecular oncology · 2023Article
- Reelin through the years: From brain development to inflammation.Cell reports · 2023Review
- Identification and Validation ofCells · 2022Article
- The Prognostic and Therapeutic Implications of the Chemoresistance Gene BIRC5 in Triple-Negative Breast Cancer.Cancers · 2022Article
- Reelin Protects against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression.Biology · 2022Article
- Neuronal exposure induces neurotransmitter signaling and synaptic mediators in tumors early in brain metastasis.Neuro-oncology · 2022Article
- Reelin depletion alleviates multiple myeloma bone disease by promoting osteogenesis and inhibiting osteolysis.Cell death discovery · 2021Article
- Evidence of Reelin Signaling in GBM and Its Derived Cancer Stem Cells.Brain sciences · 2021Article
- Article
- Functional Heterogeneity of Reelin in the Oral Squamous Cell Carcinoma Microenvironment.Frontiers in oncology · 2021Article
- Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment.Hereditas · 2020Article
- Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer.BMC microbiology · 2020Article
- Intra-day variations of blood reelin levels in healthy individuals.Archives of medical science : AMS · 2020Article
- Identification of Apolipoprotein E as a Potential Diagnostic Biomarker of Nasopharyngeal Carcinoma.Cancer management and research · 2020Article
- CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features.Frontiers in genetics · 2019Article
- Patterns of Mutation Enrichment in Metastatic Triple-Negative Breast Cancer.Clinical Medicine Insights. Oncology · 2019Article
- Identification of a gene signature for different stages of breast cancer development that could be used for early diagnosis and specific therapy.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
Reelin is a secreted, signaling protein associated with neuronal cell positioning and migration. Recently, reelin was found to be epigenetically silenced in gastric and pancreatic cancers in which down-regulation was associated with increased migratory ability and reduced survival. Here we analyzed reelin expression by immunohistochemistry in 17 normal breast tissue samples from reduction mammoplasties and in two independent tissue microarrays of 136 and more than 2000 breast cancer biopsy samples, respectively. Results were analyzed with regard to clinical parameters, including BRE (Bloom, Richardson, Elston) grade, nodal status, estrogen receptor and HER2 status, and overall survival. Reelin was expressed in the luminal epithelium and myoepithelium of the normal human breast but not in cancerous breasts. Loss of reelin protein expression correlated significantly with decreased survival (P=0.01) and positive lymph node status (P<0.001). By measuring reelin expression and promoter methylation status in 39 primary breast tumors, as well as in breast cancer-derived cell lines before and after decitabine treatment, we established that reelin expression levels correlated inversely with promoter methylation status, whereas demethylation increased reelin mRNA expression in vitro. Reelin overexpression in MDA-MB231 cells, as well as incubation with recombinant reelin, suppressed cell migration, invadopodia formation, and invasiveness in vitro. We conclude that reelin may play an important role in controlling invasiveness and metastatic potential of breast cancer cells and that its expression is controlled by promoter methylation.
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