ArticleJournal of the American Society of Nephrology : JASN2010
Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis.
Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice.Cell death discovery · 2024Article
- Fibroblast p90RSK induces epithelial transdifferentiation through oxidative stress-mediated β-catenin pathway.Clinical and translational medicine · 2023Article
- miRNA biomarkers in renal disease.International urology and nephrology · 2022Review
- Article
- Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury.Frontiers in cell and developmental biology · 2021Article
- Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury.Frontiers in immunology · 2021Article
- The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk.The Journal of biological chemistry · 2019Article
- Proximal TubuleThe Journal of pharmacology and experimental therapeutics · 2019Article
- Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes.Acta physiologica (Oxford, England) · 2019Article
- Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition.Frontiers in physiology · 2018Article
- Podocyte-specific NF-κB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice.Clinical and experimental nephrology · 2017Article
- Podocyte NF-κB is dispensable for the pathogenesis of renal ischemia-reperfusion injury.Physiological reports · 2016Article
- Article
- Effects of cell-type-specific expression of a pan-caspase inhibitor on renal fibrogenesis.Clinical and experimental nephrology · 2015Article
- Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.American journal of physiology. Renal physiology · 2015Article
- Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells.In vitro cellular & developmental biology. Animal · 2015Article
- Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.American journal of physiology. Renal physiology · 2014Article
- miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction.Scientific reports · 2014Article
- SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.PLoS genetics · 2014Article
- Chronic kidney disease: Fibrosis and anaemia in CKD--two beasts, one ancestor.Nature reviews. Nephrology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
It is not clear whether interstitial fibroblasts or tubular epithelial cells are primarily responsible for the profibrotic effects of NF-κB activation during renal fibrogenesis. Here, we crossed mice carrying a conditional IκB dominant-negative transgene (IκBdN) with mice transgenic for cell-specific FSP1.Cre (FSP1(+) fibroblasts) or γGT.Cre (proximal tubular epithelia) and challenged all progeny with unilateral ureteral obstruction. We determined NF-κB activation by nuclear localization of phosphorylated p65 ((p)p65) in renal tissues after 7 days. We observed inhibition of NF-κB activation in interstitial cells and tubular epithelia in obstructed kidneys of FSP1.Cre;IκBdN and γGT.Cre;IκBdN mice, respectively, compared with IκBdN controls (P < 0.05). Deposition of extracellular matrix, however, was significantly lower in the obstructed kidneys of FSP1.Cre;IκBdN mice but not in γGT.Cre;IκBdN mice (P < 0.05). In addition, levels of mRNA encoding the profibrotic PAI-1, fibronectin-EIIIA, and type I (α1) procollagen were significantly lower in obstructed kidneys of FSP1.Cre;IκBdN mice compared with γGT.Cre;IκBdN mice (P < 0.05). Taken together, these data support a profibrotic role for fibroblasts, but not proximal tubular epithelial cells, in modulating NF-κB activation during renal fibrogenesis.
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Registered trials
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