ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Muscle energetics changes throughout maturation: a quantitative 31P-MRS analysis.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Pooled it
- High-Temporal-Resolution Monitoring of Creatine and Phosphocreatine Dynamics in Skeletal Muscle Using Ultrafast Z-Spectroscopy (UFZ) CEST MRI at 3T.Magnetic resonance in medicine · 2026Article
- Small-Sided Games vs. Running-Based High-Intensity Interval Training: An Exploratory Study of the Effects on Physical Performance and Internal Load in Under-11 Male Football Players.Sports (Basel, Switzerland) · 2026Article
- Developmental bioenergetics: a comparative perspective on mitochondrial efficiency in paediatric physiology.The Journal of physiology · 2026Article
- Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T.Magnetic resonance in medicine · 2025Article
- Determinants of pre-adolescent girls' sport performance in three-year swimming training.Frontiers in sports and active living · 2025Article
- Simultaneous creatine and phosphocreatine mapping of skeletal muscle by CEST MRI at 3T.Magnetic resonance in medicine · 2024Article
- Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues.NMR in biomedicine · 2023Review
- Article
- High-Intensity Interval Training for Rowing: Acute Responses in National-Level Adolescent Males.International journal of environmental research and public health · 2022Article
- Influence of Advancing Biological Maturation on Aerobic and Anaerobic Power and on Sport Performance of Junior Rowers: A Longitudinal Study.Frontiers in physiology · 2022Article
- Sex-related differences in accumulated OEuropean journal of applied physiology · 2021Article
- Influence of Biological Maturity on the Muscular Strength of Young Male and Female Swimmers.Journal of human kinetics · 2021Article
- Eccentric Resistance Training in Youth: A Survey of Perceptions and Current Practices by Strength and Conditioning Coaches.Journal of functional morphology and kinesiology · 2021Article
- Heart Rate Responses during Sport-Specific High-Intensity Circuit Exercise in Child Female Gymnasts.Sports (Basel, Switzerland) · 2020Article
- Effect of Long-Duration Adventure Races on Cardiac Damage Biomarker Release and Muscular Function in Young Athletes.Frontiers in physiology · 2020Article
- Maturation-related changes in the development and etiology of neuromuscular fatigue.European journal of applied physiology · 2019Article
- Children Exhibit a More Comparable Neuromuscular Fatigue Profile to Endurance Athletes Than Untrained Adults.Frontiers in physiology · 2019Article
- Exercise-induced fatigue in young people: advances and future perspectives.European journal of applied physiology · 2018Review
- Metabolic and Fatigue Profiles Are Comparable Between Prepubertal Children and Well-Trained Adult Endurance Athletes.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We quantified energy production in 7 prepubescent boys (11.7 ± 0.6 yr) and 10 men (35.6 ± 7.8 yr) using (31)P-magnetic resonance spectroscopy to investigate whether development affects muscle energetics, given that resistance to fatigue has been reported to be larger before puberty. Each subject performed a finger flexions exercise at 0.7 Hz against a weight adjusted to 15% of their maximal voluntary strength for 3 min, followed by a 15-min recovery period. The total energy cost was similar in both groups throughout the exercise bout, whereas the interplay of the different metabolic pathways was different. At the onset of exercise, children exhibited a higher oxidative contribution (50 ± 15% in boys and 25 ± 8% in men, P < 0.05) to ATP production, whereas the phosphocreatine breakdown contribution was reduced (40 ± 10% in boys and 53 ± 12% in men, P < 0.05), likely as a compensatory mechanism. The anaerobic glycolysis activity was unaffected by maturation. The recovery phase also disclosed differences regarding the rates of proton efflux (6.2 ± 2.5 vs. 3.8 ± 1.9 mM · pH unit(-1) · min(-1), in boys and men, respectively, P < 0.05), and phosphocreatine recovery, which was significantly faster in boys than in men (rate constant of phosphocreatine recovery: 1.3 ± 0.5 vs. 0.7 ± 0.4 min(-1); V(max): 37.5 ± 14.5 vs. 21.1 ± 12.2 mM/min, in boys and men, respectively, P < 0.05). Our results obtained in vivo clearly showed that maturation affects muscle energetics. Children relied more on oxidative metabolism and less on creatine kinase reaction to meet energy demand during exercise. This phenomenon can be explained by a greater oxidative capacity, probably linked to a higher relative content in slow-twitch fibers before puberty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.