ArticleInvestigative ophthalmology & visual science2011
Magnetic resonance imaging of vascular oxygenation changes during hyperoxia and carbogen challenges in the human retina.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.Scientific reports · 2024Article
- Intracellular oxygen mapping using a myoglobin-mCherry probe with fluorescence lifetime imaging.Journal of biomedical optics · 2018Article
- Risk factors for poor outcomes in patients with open-globe injuries.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Computational model for oxygen transport and consumption in human vitreous.Investigative ophthalmology & visual science · 2013Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.Magnetic resonance in medicine · 2012Article
- Layer-specific manganese-enhanced MRI of the retina in light and dark adaptation.Investigative ophthalmology & visual science · 2012Article
- 3D magnetic resonance microscopy of the ex vivo retina.Magnetic resonance in medicine · 2012Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
- Manganese-enhanced MRI reveals multiple cellular and vascular layers in normal and degenerated retinas.Journal of magnetic resonance imaging : JMRI · 2011Article
- Lamina-specific anatomic magnetic resonance imaging of the human retina.Investigative ophthalmology & visual science · 2011Article
- Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat.Biomedical optics express · 2011Article
- Anatomical, blood oxygenation level-dependent, and blood flow MRI of nonhuman primate (baboon) retina.Magnetic resonance in medicine · 2011Article
- Lamina-specific functional MRI of retinal and choroidal responses to visual stimuli.Investigative ophthalmology & visual science · 2011Article
- Effects of common anesthetics on eye movement and electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2011Article
- Magnetic resonance imaging of the retina: A brief historical and future perspective.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo demonstrate blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) of vascular oxygenation changes in normal, unanesthetized human retinas associated with oxygen and carbogen challenge.
methodsMRI was performed with a 3-T human scanner and a custom-made surface-coil detector on normal volunteers. BOLD MRI with inversion recovery was used to suppress the vitreous signal. During MRI measurements, volunteers underwent three episodes of air and 100% oxygen or carbogen (5% CO(2) and 95% O(2)) breathing. Eye movement was effectively managed with eye fixation, synchronized blinks, and postprocessing image coregistration. BOLD time-series images were analyzed using the cross-correlation method. Percent changes due to oxygen or carbogen inhalation versus air were tabulated for whole-retina and different regions of the retina.
resultsRobust BOLD responses were detected. BOLD MRI percent change from a large region of interest at the posterior pole of the retina was 5.2 ± 1.5% (N = 9 trials from five subjects) for oxygen inhalation and 5.2 ± 1.3% (N = 11 trials from five subjects) for carbogen inhalation. Group-averaged BOLD percent changes were not significantly different between oxygen and carbogen challenges (P > 0.05). The foveal region had greater BOLD response compared with the optic nerve head region for both challenges.
conclusionsBOLD retinal responses to oxygen and carbogen breathing in unanesthetized humans can be reliably imaged at high spatiotemporal resolution. BOLD MRI has the potential to provide a valuable tool to study retinal physiology and pathophysiology, such as how vascular oxygenation at the tissue level is regulated in the normal retina, and how retinal diseases may affect oxygen response.
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Registered trials
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