ArticleThe Journal of biological chemistry2010
The forkhead transcription factor Hcm1 promotes mitochondrial biogenesis and stress resistance in yeast.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Insights into the Lysine Acetylome of the HaloarchaeonAntioxidants (Basel, Switzerland) · 2023Article
- Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains.Biotechnology for biofuels and bioproducts · 2022Review
- Mitochondrial Localization of the Yeast Forkhead Factor Hcm1.International journal of molecular sciences · 2020Article
- Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases.Biomolecules · 2020Review
- Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity.Redox biology · 2019Article
- Transcriptomic analysis of thermotolerant yeastRSC advances · 2018Article
- The ubiquitin-conjugating enzyme, Ubc1, indirectly regulates SNF1 kinase activity via Forkhead-dependent transcription.Microbial cell (Graz, Austria) · 2016Article
- Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity.Current genetics · 2016Review
- Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration.Molecular and cellular biology · 2016Article
- Sch9 regulates intracellular protein ubiquitination by controlling stress responses.Redox biology · 2015Article
- The diversity of histone versus nonhistone sirtuin substrates.Genes & cancer · 2013Article
- Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions.Frontiers in physiology · 2013Article
- Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.Genome biology · 2012Article
- Reactive oxygen species-mediated control of mitochondrial biogenesis.International journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Saccharomyces cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics, and budding. We found that Hcm1 interacts with the histone deacetylase Sir2 and shifts from cytoplasm to the nucleus in the G(1)/S phase or in response to oxidative stress stimuli. The nuclear localization of Hcm1 depends on the activity of Sir2 as revealed by activators and inhibitors of the sirtuins and the Δsir2 mutant. Hcm1-overexpressing cells display more mitochondria that can be attributed to increased amounts of Abf2, a protein involved in mitochondrial biogenesis. These cells also show higher rates of oxygen consumption and improved resistance to oxidative stress that would be explained by increased catalase and Sod2 activities and molecular chaperones such as Hsp26, Hsp30, and members of Hsp70 family. Microarray analyses also reveal increased expression of genes involved in mitochondrial energy pathways and those allowing the transition from the exponential to the stationary phase. Taken together, these results describe a new and relevant role of Hcm1 for mitochondrial functions, suggesting that this transcription factor would participate in the adaptation of cells from fermentative to respiratory metabolism.
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