ArticleJournal of neuroimmunology2011
Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.
Article in Journal of neuroimmunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination.Brain pathology (Zurich, Switzerland) · 2021Article
- Granulocyte-macrophage colony-stimulating factor mRNA and Neuroprotective Immunity in Parkinson's disease.Biomaterials · 2021Article
- Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders.Molecular neurodegeneration · 2020Review
- Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections.International journal of molecular sciences · 2020Review
- Imaging the Neuroimmune Dynamics Across Space and Time.Frontiers in neuroscience · 2020Review
- Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine.Frontiers in cellular neuroscience · 2018Article
- Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders.Translational neurodegeneration · 2014Review
- Bridge between neuroimmunity and traumatic brain injury.Current pharmaceutical design · 2014Review
- Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Drug induced increases in CNS dopamine alter monocyte, macrophage and T cell functions: implications for HAND.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Commentary: Animal models of neuroAIDS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- HIV-1 immunopathogenesis in humanized mouse models.Cellular & molecular immunology · 2012Review
- Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.Journal of neurotrauma · 2012Article
- The Roles and Perspectives of Toll-Like Receptors and CD4(+) Helper T Cell Subsets in Acute Viral Encephalitis.Immune network · 2012Article
- Rodent models for HIV-associated neurocognitive disorders.Trends in neurosciences · 2012Review
- In vivo SPECT reporter gene imaging of regulatory T cells.PloS one · 2011Article
- Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage.Journal of proteome research · 2010Article
- Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Science China. Life sciences · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, relationships between Treg ingress of end organ tissues, notably the brain, and neuroprotection were investigated. Treg from EGFP-transgenic donor mice were expanded, labeled with indium-111, and adoptively transferred. Treg distribution was assayed by single photon emission computed tomography and immunohistochemistry. Treg readily migrated across the blood brain barrier and were retained within virus-induced neuroinflammatory sites. In non-inflamed peripheral tissues (liver and spleen) Treg were depleted. These observations demonstrate that Treg migrate to sites of inflammation where they modulate immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.