Evidence map›Paper›PMID 20846583›Full record

ArticleDiagnostic microbiology and infectious disease2010

Pathotypes of diarrheagenic Escherichia coli in children attending a tertiary care hospital in South India.

Priya Rajendran, Sitara Swarna Rao Ajjampur, Divya Chidambaram, Gunasekaran Chandrabose, Bhuvaneswari Thangaraj, Rajiv Sarkar, Prasanna Samuel, Deva Prasanna Rajan, Gagandeep Kang

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Enteroaggregative Escherichia coli and acute diarrhea in children: a meta-analysis of South Asian populations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013
    Pooled it
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  6. DiarrhoeagenicAfrican health sciences · 2022
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  7. Phylogrouping and characterization ofFrontiers in medicine · 2022
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  11. Evaluation of LAMP for detection ofAccess microbiology · 2020
    Article
  12. Bacterial Contamination of Children's Toys in Rural Day Care Centres and Households in South Africa.International journal of environmental research and public health · 2019
    Article
  13. Surveillance for enterotoxigenic & enteropathogenicThe Indian journal of medical research · 2019
    Article
  14. Article
  15. Molecular Characterization and Antimicrobial Resistance Pattern ofInternational journal of environmental research and public health · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Gastroenterology and hepatology from bed to bench · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Priya RajendranDepartment of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
Sitara Swarna Rao Ajjampur
Divya Chidambaram
Gunasekaran Chandrabose
Bhuvaneswari Thangaraj
Rajiv Sarkar
Prasanna Samuel
Deva Prasanna Rajan
Gagandeep Kang

Funding

Multi-disciplinary research training in enteric infectionsD43TW007392 · FIC · CHRISTIAN MEDICAL COLLEGE · PI KANG, GAGANDEEP · 2005 to 2020
$2.9M
FIC NIH HHS D43 TW007392
6 · The paper itself

Abstract

The prevalence of diarrheagenic Escherichia coli (DEC) in children under 5 years was studied in children with diarrhea and controls in South India. Four polymerase chain reaction (PCR) "schemes" were used to detect genes of the 6 pathotypes of DEC. In 394 children with diarrhea, 203 (52%) DEC infections were found. Among the 198 controls, 126 (63%) DEC infections were found. Enteroaggregative E. coli was the most common pathotype by multiplex PCR both in cases (58, 14.7%) and controls (47, 23.7%), followed by enteropathogenic E. coli seen in 10% cases and 8% of controls. Enterotoxigenic E. coli (ETEC), enterohemorrhagic E. coli (EHEC), enteroinvasive E. coli (EIEC), and diffusely adherent E. coli (DAEC) were found in 4.1%, 2.0%, 1.0%, and 0.5% of cases, respectively. ETEC was found in 2.5% of controls, but EHEC, EIEC, and DAEC were not detected. Overall, no single assay worked well, but by discounting genes with a pathogenicity index of less than 1, it was possible to use the PCR assays to identify DEC in 75/394 (19%) cases and 12/198 (6.1%) controls, while mixed infection could be identified in 8/394 (2%) cases and 2/198 (1%) controls.

Indexed as

Child, PreschoolDiarrheaDNA, BacterialEnterohemorrhagic Escherichia coliEnteropathogenic Escherichia coliEnterotoxigenic Escherichia coliEscherichia coliEscherichia coli InfectionsFecesGenetic VariationHumansIndiaInfantInfant, NewbornMolecular EpidemiologyPolymerase Chain ReactionDNA, Bacterial

Identifiers

PMID20846583
PMCPMC3918514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.