ArticleBrain research2010
Characterization of sensory neurons in the dorsal root ganglia of Bax-deficient mice.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition.Neural development · 2023Article
- Glutamine Maintains Satellite Glial Cells Growth and Survival in Culture.Neurochemical research · 2022Article
- Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism.Nature biomedical engineering · 2022Article
- Open-source method of image cytometry in dorsal root ganglia tissue with immunofluorescence.Analytical biochemistry · 2021Article
- Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth.JOR spine · 2020Article
- Hydroxylated Fullerene: A Stellar Nanomedicine to Treat Lumbar Radiculopathy via Antagonizing TNF-ACS biomaterials science & engineering · 2018Article
- The Suprachiasmatic Nucleus of the Dromedary Camel (Frontiers in neuroanatomy · 2017Article
- Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adultJournal of pain research · 2017Article
- Peripheral somatosensation: a touch of genetics.Current opinion in genetics & development · 2011Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
During development, the rescue of spinal motoneurons as well as sensory neurons in the dorsal root ganglion (DRG) from programmed cell death (PCD) depends on the integrity of peripheral target innervation. Following deletion of the pro-apoptotic gene Bax, both motoneurons and DRG neurons are rescued from PCD. In the present paper, we asked whether different cell types in the DRG exhibit distinct responses to Bax deletion. In 1-month-old Bax-deficient (Bax-/-) mice, distinct subsets of DRG neurons that were immunopositive for TrkA, CGRP, TRPV1 or TrkC, were all increased in number and exhibited cell atrophy compared to wild type DRG neurons. In addition there was hyperinnervation of the epidermis by CGRP immunopositive processes and a correlated functional hypersensitivity of mechanical nociception in Bax-/- mice. By contrast, the functional properties of populations of rescued thermoreceptor and mechanoreceptor DRG neurons were unchanged. These data indicate that although Bax deletion rescues all of the DRG cell types examined here from PCD, the functional consequences of having excess cells differ between sensory phenotypes.
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Registered trials
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