ArticleInternational journal of pediatric otorhinolaryngology2010
Mucin gene expression and mouse middle ear epithelium.
Article in International journal of pediatric otorhinolaryngology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The barrier and protective functions of intestinal mucin in defense againstFrontiers in microbiology · 2025Review
- TheFrontiers in cellular and infection microbiology · 2021Article
- Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.PloS one · 2021Article
- An in vitro model of murine middle ear epithelium.Disease models & mechanisms · 2016Article
- C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis.Oncotarget · 2016Article
- Notch signaling is active in normal mouse middle ear epithelial cells.Experimental and therapeutic medicine · 2016Article
- A melting method for RNA extraction from the mucosal membrane of the mouse middle ear.Yonsei medical journal · 2015Article
- Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2013Review
- A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse.International journal of pediatric otorhinolaryngology · 2013Article
- Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the expression of recently identified human mucin genes in an in vitro model of cultured mouse middle ear epithelial cells (MMEEC).
methodsMMEEC were established, RNA was extracted and primers were designed for RT-PCR to assess for expression of mucin genes Muc1, Muc2, Muc3, Muc4, Muc5AC, Muc5B, Muc6, Muc7, Muc8, Muc9, Muc10, Muc11/12, Muc13, Muc15, Muc16, Muc17, Muc18, Muc19 and Muc20 expression.
resultsMucin genes Muc1, Muc2, Muc3, Muc4, Muc5AC, Muc5B, Muc9, Muc10, Muc13, Muc15, Muc16, Muc18, Muc19 and Muc20 were identified and expressed in MMEEC. The genes Muc6, Muc7, Muc8, Muc11/12 and Muc17 were not identified.
conclusionMany of the mucin genes that have been recently identified in human MEE and chinchilla MEE are also expressed in MMEEC. There are differences in expression, however, which may have implications in utilizing various animal models for study of middle ear physiology and pathogenesis; specifically as it relates to mucin gene expression.
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