ArticleMolecular brain2010
Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice.
Article in Molecular brain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Experiencing pain: electromagnetic waves, consciousness, and the mind.Frontiers in human neuroscience · 2025Article
- Synaptic sensitization in the anterior cingulate cortex sustains the consciousness of pain via synchronized oscillating electromagnetic waves.Frontiers in human neuroscience · 2024Article
- Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.Biomedicines · 2022Review
- The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders.International journal of molecular sciences · 2021Review
- Pre-LTP requires extracellular signal-regulated kinase in the ACC.Molecular pain · 2016Article
- Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome.Neural plasticity · 2016Review
- Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats.Behavioral and brain functions : BBF · 2015Article
- Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice.Molecular pain · 2014Article
- Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Uncoupling PSD-95 interactions leads to rapid recovery of cortical function after focal stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Running-induced epigenetic and gene expression changes in the adolescent brain.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.Journal of neurophysiology · 2013Article
- Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes.Molecular brain · 2012Article
- Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning.Molecular brain · 2012Article
- Hyperalgesia by synaptic long-term potentiation (LTP): an update.Current opinion in pharmacology · 2012Review
- Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Interplay of amygdala and cingulate plasticity in emotional fear.Neural plasticity · 2011Review
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP-responsive element binding protein (CREB), which plays key roles in synaptic plasticity and memory consolidation. Our previous study showed that long-term potentiation (LTP) in the anterior cingulate cortex (ACC) was significantly enhanced in transgenic mice overexpressing CaMKIV. Considering that the CaMKIV-CREB pathway plays a central role in the protein synthesis-dependent LTP, it is possible that upregulation of CaMKIV contributes to enhancement of LTP by promoting protein synthesis. To test this possibility, we examined the effects of transcription and translation inhibitors on synaptic potentiation induced by pairing of synaptic activity with postsynaptic depolarization (paired training) in ACC pyramidal neurons of wild-type and CaMKIV transgenic mice. We found that synaptic potentiation induced by paired training was partially inhibited by transcription or translation inhibitors both in wild-type and CaMKIV transgenic mice; the extent of inhibition was markedly larger in the CaMKIV transgenic mice than in the wild-type mice. Biochemical and immunohistochemical studies revealed that CaMKIV was distributed in the membrane, cytosol and nucleus of ACC neurons. Our results reveal in the first time a transcription- and translation-dependent component of early synaptic LTP in adult ACC synapses, and demonstrate that CaMKIV enhances early synaptic potentiation by activating new protein synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.