ArticleAnnals of human genetics2010
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
Article in Annals of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- [Prospects and mechanistic insights into the use of recombinant human growth hormone in the treatment of pediatric inflammatory bowel disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression.Digestive diseases and sciences · 2025Article
- ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2.Journal of virology · 2021Article
- The Association of ATG16L1 Variations with Clinical Phenotypes of Adult-Onset Still's Disease.Genes · 2021Article
- Growth and Puberty in Children with Inflammatory Bowel Diseases.Biomedicines · 2020Review
- Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines.Heliyon · 2020Article
- Growth failure in pediatric onset inflammatory bowel disease: mechanisms, epidemiology, and management.Translational pediatrics · 2019Review
- Genome-wide interrogation of longitudinal FEV1 in children with asthma.American journal of respiratory and critical care medicine · 2014Article
- Sex differences in statural growth impairment in Crohn's disease: role of IGF-1.Inflammatory bowel diseases · 2011Article
- Impact of Inflammatory Bowel Disease upon Growth in Children and Adolescents.ISRN pediatrics · 2011Article
- Impact of pediatric inflammatory bowel disease on linear growth: Data from a national cohort study in Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Marco Ramoni: an appreciation of academic achievement.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
The etiology of growth impairment in Crohn's disease (CD) has been inadequately explained by nutritional, hormonal, and/or disease-related factors, suggesting that genetics may be an additional contributor. The aim of this cross-sectional study was to investigate genetic variants associated with linear growth in pediatric-onset CD. We genotyped 951 subjects (317 CD patient-parent trios) for 64 polymorphisms within 14 CD-susceptibility and 23 stature-associated loci. Patient height-for-age Z-score < -1.64 was used to dichotomize probands into growth-impaired and nongrowth-impaired groups. The transmission disequilibrium test (TDT) was used to study association to growth impairment. There was a significant association between growth impairment in CD (height-for-age Z-score < -1.64) and a stature-related polymorphism in the dymeclin gene DYM (rs8099594) (OR = 3.2, CI [1.57-6.51], p = 0.0007). In addition, there was nominal over-transmission of two CD-susceptibility alleles, 10q21.1 intergenic region (rs10761659) and ATG16L1 (rs10210302), in growth-impaired CD children (OR = 2.36, CI [1.26-4.41] p = 0.0056 and OR = 2.45, CI [1.22-4.95] p = 0.0094, respectively). Our data indicate that genetic influences due to stature-associated and possibly CD risk alleles may predispose CD patients to alterations in linear growth. This is the first report of a link between a stature-associated locus and growth impairment in CD.
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Registered trials
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