ReviewPlanta medica2011
Uterotonic plants and their bioactive constituents.
Review in Planta medica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Review of the ethnobotany, phytochemistry, pharmacology, and toxicity studies of the genusFrontiers in pharmacology · 2025Review
- Perspectives of midwives on the use of Kaligutim (local oxytocin) for induction of labour among pregnant women in the government hospitals in Tamale.BMC pregnancy and childbirth · 2024Article
- Article
- Magnitude and Associated Factors of Herbal Medicine Use During Pregnancy Among Women Attending Antenatal Care in Public Health Institutions of Central Tigray, Northern Ethiopia (2020): Facility-Based Cross-Sectional Study.Journal of pregnancy · 2024Article
- Evaluation of Uterotonic Activity, Acute Oral Toxicity, and Phytochemical Composition ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Drug discovery strategies for the identification of novel regulators of uterine contractility.Current opinion in physiology · 2020Article
- The Uterotonic Screening of the Root Extract ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Oxytocin/vasopressin-like neuropeptide signaling in insects.Vitamins and hormones · 2020Review
- I8-arachnotocin-an arthropod-derived G protein-biased ligand of the human vasopressin VScientific reports · 2019Article
- Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin-derived products.EFSA journal. European Food Safety Authority · 2019Article
- Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine.Frontiers in physiology · 2019Article
- Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Article
- Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development.Journal of visualized experiments : JoVE · 2018Article
- Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor.Frontiers in pharmacology · 2017Article
- Prevalence and factors associated with use of herbal medicines during pregnancy among women attending postnatal clinics in Gulu district, Northern Uganda.BMC pregnancy and childbirth · 2016Article
- Herbal medicine use and linked suspected adverse drug reactions in a prospective cohort of Ugandan inpatients.BMC complementary and alternative medicine · 2016Article
- An exploration of village-level uterotonic practices in Fenerive-Est, Madagascar.BMC pregnancy and childbirth · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Abnormalities in the process of uterine muscle contractility during pregnancy and birth can have major clinical implications, including preterm labour, which is the single largest cause of maternal and prenatal mortality in the Western world and a major contributor to childhood developmental problems. In contrast, induction of labour may be necessary in certain conditions. Currently used interventional therapies to suppress (tocolytic agents) or to induce (uterotonic agents) uterine contractions lack potency and/or selectivity and can have harmful side effects for mother and baby. Nature's diversity has always been, and still is, one of the biggest resources of therapeutic lead compounds. Many natural products exhibit biological activity against unrelated targets, thus providing researchers with starting points for drug development. In this review we will provide an overview of uterine muscle physiology, describe currently available biological screening procedures for testing of uterotonic plant compounds and will summarise traditionally-used uterotonic plants, their active components and their mechanisms, primarily focusing on uterotonic active circular plant peptides called cyclotides. Finally we will comment on the discovery of novel cyclotide-producing plant species and the possibility for the development of novel plant-derived uterotonic and tocolytic drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.